Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4422086..4422732 Replicon chromosome
Accession NZ_CP028990
Organism Klebsiella pneumoniae strain AR_0142

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AM389_RS22205 Protein ID WP_023317328.1
Coordinates 4422086..4422433 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM389_RS22210 Protein ID WP_032412314.1
Coordinates 4422433..4422732 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM389_RS22195 4418012..4419445 + 1434 WP_004145113.1 glycogen synthase GlgA -
AM389_RS22200 4419463..4421910 + 2448 WP_002920561.1 glycogen phosphorylase -
AM389_RS22205 4422086..4422433 + 348 WP_023317328.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM389_RS22210 4422433..4422732 + 300 WP_032412314.1 XRE family transcriptional regulator Antitoxin
AM389_RS22215 4422795..4424303 - 1509 WP_032412313.1 glycerol-3-phosphate dehydrogenase -
AM389_RS22220 4424508..4424837 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
AM389_RS22225 4424888..4425718 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
AM389_RS22230 4425768..4426526 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13562.60 Da        Isoelectric Point: 6.2327

>T104554 WP_023317328.1 NZ_CP028990:4422086-4422433 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
ILCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T104554 NZ_CP028990:4422086-4422433 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
ATTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10828.64 Da        Isoelectric Point: 10.1464

>AT104554 WP_032412314.1 NZ_CP028990:4422433-4422732 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGIKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT104554 NZ_CP028990:4422433-4422732 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGATAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References