Detailed information of TA system TA104535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 4664934..4665457
• Replicon: chromosome
• Accession: NZ_CP028968
• Organism: Aminobacter sp. MSH1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DCS14_RS23535
• Protein ID: WP_108608975.1
• Coordinates: 4664934..4665206 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: DCS14_RS23540
• Protein ID: WP_108608976.1
• Coordinates: 4665206..4665457 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCS14_RS23515	4660083..4661861	-	1779	WP_108608971.1	acyl-CoA dehydrogenase	-
DCS14_RS23520	4662030..4662275	+	246	WP_108608972.1	hypothetical protein	-
DCS14_RS23525	4662327..4663523	+	1197	WP_108608973.1	muramidase	-
DCS14_RS23530	4663547..4664824	-	1278	WP_108608974.1	phosphoribosylamine--glycine ligase	-
DCS14_RS23535	4664934..4665206	-	273	WP_108608975.1	Txe/YoeB family addiction module toxin	Toxin
DCS14_RS23540	4665206..4665457	-	252	WP_108608976.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DCS14_RS23545	4665558..4666541	+	984	WP_108608977.1	4-hydroxybenzoate octaprenyltransferase	-
DCS14_RS23550	4666542..4667108	-	567	WP_108608978.1	hypothetical protein	-
DCS14_RS23555	4667276..4668706	-	1431	WP_108608979.1	FAD-binding oxidoreductase	-
DCS14_RS23560	4668722..4669660	-	939	WP_199914651.1	threonylcarbamoyl-AMP synthase	-
DCS14_RS23565	4669862..4670266	+	405	WP_108608981.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10571.02 Da
• Isoelectric Point: 9.5786

>T104535 WP_108608975.1 NZ_CP028968:c4665206-4664934 [Aminobacter sp. MSH1]
MLIIFSEASWSDYLFWQQSDRTVCNRINELIKDTRRSPFVGIGKPEPLSGNFAGFWSRRITREHRLVYRVTGKGDTQALE
IAACRYHYDK

Nucleotide

• Length: 273 bp

>T104535 NZ_CP028968:c4665206-4664934 [Aminobacter sp. MSH1]
ATGCTGATCATTTTTTCGGAAGCCTCCTGGTCCGATTATCTGTTCTGGCAGCAGAGCGATAGGACCGTTTGCAACCGCAT
CAATGAACTCATCAAGGATACTAGGCGCTCGCCCTTCGTCGGCATTGGCAAGCCCGAGCCGCTTTCCGGCAATTTTGCCG
GCTTCTGGTCGCGCCGTATCACGCGCGAGCACCGGCTCGTCTATCGGGTGACCGGCAAGGGCGATACCCAGGCCTTGGAG
ATTGCCGCCTGCCGCTATCATTACGACAAGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9528.81 Da
• Isoelectric Point: 4.6941

>AT104535 WP_108608976.1 NZ_CP028968:c4665457-4665206 [Aminobacter sp. MSH1]
MTYVTLTELRANMAKHFDKVEEDRIELVVTRQNHEPMVVMALSELEGLRETLHLLSSRANAEHLQRSIDELNAGTGLERD
LIE

Nucleotide

• Length: 252 bp

>AT104535 NZ_CP028968:c4665457-4665206 [Aminobacter sp. MSH1]
ATGACGTATGTCACGCTTACCGAACTTCGCGCCAACATGGCCAAGCATTTCGACAAGGTCGAGGAAGACCGGATCGAATT
GGTGGTGACTAGGCAGAATCATGAGCCGATGGTGGTCATGGCCCTGTCCGAGCTTGAGGGGCTTCGCGAAACCCTGCATT
TGCTGAGTTCGCGTGCCAACGCCGAGCATCTCCAGCGCTCCATCGATGAACTCAATGCTGGCACCGGCCTCGAACGAGAC
CTCATCGAGTGA