Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 261436..262051 Replicon chromosome
Accession NZ_CP028962
Organism Burkholderia sp. IDO3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DCN14_RS01245 Protein ID WP_096500683.1
Coordinates 261710..262051 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DCN14_RS01240 Protein ID WP_096500685.1
Coordinates 261436..261723 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCN14_RS01210 256916..257737 + 822 WP_096500693.1 SDR family oxidoreductase -
DCN14_RS01215 257857..258636 - 780 WP_096500691.1 5'/3'-nucleotidase SurE -
DCN14_RS01220 258834..259133 - 300 WP_096501034.1 AzlD family protein -
DCN14_RS01225 259126..259863 - 738 WP_096500689.1 AzlC family ABC transporter permease -
DCN14_RS01230 259989..260447 + 459 WP_096500687.1 Lrp/AsnC family transcriptional regulator -
DCN14_RS01235 260673..261242 + 570 WP_096501032.1 hypothetical protein -
DCN14_RS01240 261436..261723 - 288 WP_096500685.1 helix-turn-helix transcriptional regulator Antitoxin
DCN14_RS01245 261710..262051 - 342 WP_096500683.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCN14_RS01250 262284..262916 - 633 WP_096500681.1 LysE family translocator -
DCN14_RS01255 263093..263953 - 861 WP_096500679.1 hypothetical protein -
DCN14_RS01260 264004..264336 - 333 WP_096500677.1 DUF2322 family protein -
DCN14_RS01265 264457..265161 - 705 WP_096500675.1 flavin reductase family protein -
DCN14_RS01270 265392..265718 + 327 WP_096500673.1 thioredoxin family protein -
DCN14_RS01275 265729..266148 + 420 WP_096501030.1 secondary thiamine-phosphate synthase enzyme YjbQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12984.18 Da        Isoelectric Point: 9.8290

>T104516 WP_096500683.1 NZ_CP028962:c262051-261710 [Burkholderia sp. IDO3]
MMATAYEIQFFDARVETGVITLPKTLLARFFALADRMEQYGPNLGEPHTQSMGNGLYEMRLKGAEGIARVFYCAIVDRRI
VMLHCFVKKTQKTPRKELETARRRLKEVQDGNV

Download         Length: 342 bp

>T104516 NZ_CP028962:c262051-261710 [Burkholderia sp. IDO3]
ATGATGGCTACTGCGTATGAGATTCAGTTCTTCGATGCGCGCGTGGAAACGGGCGTTATCACGTTACCGAAGACGCTGCT
CGCCCGTTTTTTCGCGCTCGCCGACCGCATGGAGCAGTACGGCCCGAACCTCGGCGAGCCGCACACCCAGTCGATGGGCA
ACGGGTTGTACGAAATGCGACTCAAGGGTGCCGAAGGCATCGCCAGAGTGTTCTACTGCGCGATCGTCGACCGGCGTATC
GTCATGCTTCATTGTTTCGTGAAGAAGACGCAAAAGACGCCACGGAAAGAACTGGAAACCGCGCGCCGCCGACTGAAGGA
GGTTCAAGATGGCAACGTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10389.97 Da        Isoelectric Point: 9.9960

>AT104516 WP_096500685.1 NZ_CP028962:c261723-261436 [Burkholderia sp. IDO3]
MATYKALRERALSDPEVRAEYERLNREDLALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIDTLR
KYATACGKKLVISFA

Download         Length: 288 bp

>AT104516 NZ_CP028962:c261723-261436 [Burkholderia sp. IDO3]
ATGGCAACGTATAAGGCCCTGCGCGAGCGCGCTTTGTCCGACCCCGAGGTGCGCGCCGAATACGAACGGCTGAACCGCGA
AGACCTCGCACTGCTCGACGCGATGCTGGCCGCGCGTCGCGCCGCCGGGCTGTCGCAAGCCGATGTGGCCGAGCGCATGG
GCACGAAGGCACCGGCGGTGACGCGCCTCGAGCGCGCGCTCGCAACGGGCCAGCATTCACCGTCCATCGATACGTTGCGC
AAGTACGCAACCGCTTGCGGCAAGAAACTCGTGATCTCGTTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References