Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 481622..482316 Replicon chromosome
Accession NZ_CP028950
Organism Enterobacter cloacae complex sp. FDA-CDC-AR_0164

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag AM410_RS02385 Protein ID WP_175556434.1
Coordinates 481622..482020 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID A0A285AZA0
Locus tag AM410_RS02390 Protein ID WP_073395581.1
Coordinates 482023..482316 (-) Length 98 a.a.

Genomic Context

AM410_RS02365AM410_RS02370AM410_RS02380AM410_RS02395AM410_RS02400AM410_RS02405AM410_RS02375AM410_RS02385AM410_RS02390AM410_RS02410
Location: 477609..478373 (765 bp)
Type: Others
Protein ID: WP_014168780.1
Location: 478437..479843 (1407 bp)
Type: Others
Protein ID: WP_073395587.1
Location: 480829..481470 (642 bp)
Type: Others
Protein ID: WP_073395584.1
Location: 482856..483755 (900 bp)
Type: Others
Protein ID: WP_073395579.1
Location: 483839..484738 (900 bp)
Type: Others
Protein ID: Protein_458
Location: 484896..485633 (738 bp)
Type: Others
Protein ID: Protein_459
Location: 480028..480720 (693 bp)
Type: Others
Protein ID: WP_073395586.1
Location: 481622..482020 (399 bp)
Type: Toxin
Protein ID: WP_175556434.1
Location: 482023..482316 (294 bp)
Type: Antitoxin
Protein ID: WP_073395581.1
Location: 485642..486888 (1247 bp)
Type: Others
Protein ID: Protein_460
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AM410_RS02365477609..478373+765WP_014168780.1galactose-binding lectin-
AM410_RS02370478437..479843+1407WP_073395587.1carbohydrate binding domain-containing protein-
AM410_RS02375480028..480720-693WP_073395586.1hydrolase-
AM410_RS02380480829..481470+642WP_073395584.1TetR/AcrR family transcriptional regulator-
AM410_RS02385481622..482020-399WP_175556434.1type II toxin-antitoxin system YafO family toxinToxin
AM410_RS02390482023..482316-294WP_073395581.1type I toxin-antitoxin system antitoxin YafNAntitoxin
AM410_RS02395482856..483755+900WP_073395579.1DUF4365 domain-containing protein-
AM410_RS02400483839..484738+900Protein_458hypothetical protein-
AM410_RS02405484896..485633+738Protein_459DUF3644 domain-containing protein-
AM410_RS02410485642..486888-1247Protein_460shufflon system plasmid conjugative transfer pilus tip adhesin PilV-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15314.63 Da        Isoelectric Point: 7.1157

>T104473 WP_175556434.1 NZ_CP028950:c482020-481622 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
IRIFKSALIRQQLSQQELDDLAADFLSYKKDCVLPDTFGRDAPYDDDRTYPLVKEEQVAHIHLADADAPFPKFLRQFKRT
SDQAHLVYCQGAMDPDAYLLIIILKPEAHKMARNNNHMHKIGMMAEAFRMKH

Download         Length: 399 bp

>T104473 NZ_CP028950:c482020-481622 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
ATCAGGATTTTCAAGTCAGCACTGATCCGTCAACAATTAAGCCAACAAGAGCTTGATGATTTGGCGGCGGATTTTCTGTC
CTATAAAAAGGATTGCGTGTTGCCAGATACCTTTGGGCGTGATGCGCCTTATGATGATGACCGCACCTATCCCTTGGTAA
AAGAAGAGCAAGTGGCCCACATTCATCTTGCCGATGCGGATGCCCCTTTCCCGAAGTTTTTACGTCAGTTCAAACGAACC
AGCGATCAGGCGCATTTGGTATACTGCCAAGGTGCGATGGACCCTGATGCCTATCTGTTGATTATCATTCTGAAACCCGA
AGCGCATAAAATGGCGCGTAACAATAACCATATGCATAAGATCGGGATGATGGCCGAAGCGTTCAGGATGAAGCATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10979.44 Da        Isoelectric Point: 4.9167

>AT104473 WP_073395581.1 NZ_CP028950:c482316-482023 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
MERILAEKSINITELRKNPAKYFIDEPVAVLSNNRPAGYMVSAKVFEELIDLLEEKQGRVHTGARFRPTAERLSDIADSG
QKLLQNASDKDLTEFTE

Download         Length: 294 bp

>AT104473 NZ_CP028950:c482316-482023 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
ATGGAACGTATCCTCGCAGAAAAATCTATCAACATCACCGAGTTACGAAAGAACCCGGCGAAATATTTTATTGATGAACC
GGTTGCCGTTCTCTCAAACAACCGTCCCGCTGGCTACATGGTTAGTGCTAAGGTGTTTGAAGAGCTGATCGATCTGTTGG
AAGAGAAGCAGGGCAGGGTTCATACCGGTGCGCGATTCAGGCCAACGGCTGAACGTTTAAGTGATATTGCGGATAGTGGA
CAGAAACTGCTGCAAAACGCCTCTGACAAGGATCTGACCGAGTTCACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A285AZA0

References