Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3413451..3414103 Replicon chromosome
Accession NZ_CP028949
Organism Serratia marcescens strain AR_0121

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BTF4
Locus tag AM368_RS16220 Protein ID WP_033635775.1
Coordinates 3413759..3414103 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag AM368_RS16215 Protein ID WP_004931828.1
Coordinates 3413451..3413753 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM368_RS16190 3408459..3409106 - 648 WP_033649493.1 DsbA family protein -
AM368_RS16195 3409175..3410059 - 885 WP_048321907.1 MBL fold metallo-hydrolase -
AM368_RS16200 3410168..3411076 + 909 WP_015378928.1 LysR family transcriptional regulator -
AM368_RS16205 3411104..3412027 - 924 WP_033649494.1 LysR family transcriptional regulator -
AM368_RS16210 3412161..3413423 + 1263 WP_033649495.1 diaminopimelate decarboxylase -
AM368_RS16215 3413451..3413753 - 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
AM368_RS16220 3413759..3414103 - 345 WP_033635775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM368_RS16225 3414263..3415282 - 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
AM368_RS16235 3415503..3417761 + 2259 WP_048321906.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13409.48 Da        Isoelectric Point: 10.6087

>T104469 WP_033635775.1 NZ_CP028949:c3414103-3413759 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T104469 NZ_CP028949:c3414103-3413759 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTGCAGACGTTCGGCCCGCAGTTGACGCGGCCGCATGCCGATACGCTGTATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT104469 WP_004931828.1 NZ_CP028949:c3413753-3413451 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT104469 NZ_CP028949:c3413753-3413451 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCCATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAACACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BTF4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References