Detailed information of TA system TA104431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4913042..4913702
• Replicon: chromosome
• Accession: NZ_CP028946
• Organism: Serratia marcescens strain AR_0124

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AM371_RS23350
• Protein ID: WP_085286322.1
• Coordinates: 4913349..4913702 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2V4GQ69
• Locus tag: AM371_RS23345
• Protein ID: WP_033635213.1
• Coordinates: 4913042..4913344 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM371_RS23325	4908664..4909578	-	915	WP_004928592.1	branched-chain amino acid ABC transporter permease	-
AM371_RS23330	4909704..4910822	-	1119	WP_033647954.1	branched-chain amino acid ABC transporter substrate-binding protein	-
AM371_RS23340	4911426..4912634	-	1209	WP_039565158.1	aldose 1-epimerase family protein	-
AM371_RS23345	4913042..4913344	-	303	WP_033635213.1	XRE family transcriptional regulator	Antitoxin
AM371_RS23350	4913349..4913702	-	354	WP_085286322.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM371_RS23355	4914142..4915437	+	1296	WP_049235463.1	MFS transporter	-
AM371_RS23360	4915465..4916271	+	807	WP_085286323.1	substrate-binding domain-containing protein	-
AM371_RS23365	4916246..4917145	-	900	WP_033647959.1	LysR family transcriptional regulator	-
AM371_RS23370	4917238..4917603	-	366	WP_033635218.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13477.24 Da
• Isoelectric Point: 8.9000

>T104431 WP_085286322.1 NZ_CP028946:c4913702-4913349 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRTFFAFDPYRNGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Nucleotide

• Length: 354 bp

>T104431 NZ_CP028946:c4913702-4913349 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGACATTCTTCGCCTTCGATCCGTACCGTAACGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCGGATGATCCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11079.94 Da
• Isoelectric Point: 6.4738

>AT104431 WP_033635213.1 NZ_CP028946:c4913344-4913042 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT104431 NZ_CP028946:c4913344-4913042 [Serratia marcescens]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCTGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTAAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCGGACGGCTCTCACTACGAATTTGTGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2V4GQ69