Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 752699..753290 Replicon chromosome
Accession NZ_CP028941
Organism Polynucleobacter sp. LimPoW16

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag DCO16_RS03920 Protein ID WP_173942444.1
Coordinates 753012..753290 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DCO16_RS03915 Protein ID WP_173942443.1
Coordinates 752699..753001 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCO16_RS03875 748207..748419 + 213 WP_173942437.1 hypothetical protein -
DCO16_RS03880 748428..748808 + 381 WP_173942438.1 hypothetical protein -
DCO16_RS03885 748842..749072 + 231 WP_173942439.1 hypothetical protein -
DCO16_RS03890 749506..749768 - 263 Protein_754 type II toxin-antitoxin system PemK/MazF family toxin -
DCO16_RS03895 749831..750049 - 219 Protein_755 antitoxin -
DCO16_RS03900 750251..750979 - 729 WP_173942440.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
DCO16_RS03905 750972..751442 - 471 WP_173942441.1 helix-turn-helix transcriptional regulator -
DCO16_RS03910 751572..751889 - 318 WP_173942442.1 hypothetical protein -
DCO16_RS03915 752699..753001 - 303 WP_173942443.1 HigA family addiction module antidote protein Antitoxin
DCO16_RS03920 753012..753290 - 279 WP_173942444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCO16_RS03925 753866..754906 + 1041 WP_173942445.1 ionic transporter y4hA -
DCO16_RS03930 755254..756358 - 1105 Protein_762 glycosyl transferase -
DCO16_RS03935 756481..757365 - 885 WP_173942446.1 DUF3108 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10952.46 Da        Isoelectric Point: 8.5071

>T104408 WP_173942444.1 NZ_CP028941:c753290-753012 [Polynucleobacter sp. LimPoW16]
MIRSFGCQETEALFYSEASYRFKNVERVARRRLLQLHAVTRLEDLRIPPGNRLESLRGDRDGQYSIRINAQWRICFLWKE
DGVHGVEIVDYH

Download         Length: 279 bp

>T104408 NZ_CP028941:c753290-753012 [Polynucleobacter sp. LimPoW16]
ATGATTCGTTCTTTTGGATGCCAAGAAACCGAAGCATTGTTTTACAGCGAAGCGTCCTATCGCTTCAAAAATGTGGAGCG
AGTGGCAAGGCGTCGCTTATTGCAACTACATGCAGTGACCCGCTTGGAGGACTTACGGATACCGCCCGGAAATAGGCTGG
AATCCTTGCGTGGAGATCGAGATGGCCAATATAGTATTCGGATTAATGCACAGTGGCGCATCTGTTTTTTGTGGAAAGAG
GATGGCGTTCACGGGGTCGAAATAGTGGATTACCACTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11494.34 Da        Isoelectric Point: 6.7259

>AT104408 WP_173942443.1 NZ_CP028941:c753001-752699 [Polynucleobacter sp. LimPoW16]
MTTLLEEIHPGEILLEDFMRPLGITARQLAADIDVSPSRISEIVHGKRPISADTALRLGLFFSMDPRFWLNLQSEYDMRV
AQRTLEQHIKSRVRVFQMAA

Download         Length: 303 bp

>AT104408 NZ_CP028941:c753001-752699 [Polynucleobacter sp. LimPoW16]
ATGACAACACTACTCGAAGAAATTCACCCCGGAGAAATACTCCTAGAGGACTTTATGCGTCCGCTGGGCATTACCGCCCG
ACAGTTGGCCGCGGATATTGATGTATCCCCAAGCCGAATTAGTGAGATTGTGCATGGCAAGCGACCCATAAGCGCAGATA
CCGCCTTACGATTAGGCTTATTTTTTTCAATGGACCCACGCTTTTGGCTCAATTTGCAGTCGGAATACGATATGCGTGTT
GCACAGCGAACATTAGAACAGCACATTAAGTCACGAGTACGCGTATTTCAAATGGCTGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References