Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4473717..4474297 Replicon chromosome
Accession NZ_CP028923
Organism Roseivirga pacifica strain 9dcg1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag DCC35_RS19715 Protein ID WP_137092428.1
Coordinates 4474016..4474297 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DCC35_RS19710 Protein ID WP_137092427.1
Coordinates 4473717..4474013 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCC35_RS19680 4468742..4469152 + 411 WP_137092421.1 hypothetical protein -
DCC35_RS19685 4469293..4469733 + 441 WP_137092422.1 lipocalin family protein -
DCC35_RS19690 4469818..4470243 + 426 WP_137092423.1 hypothetical protein -
DCC35_RS19695 4470271..4470654 + 384 WP_137092424.1 VOC family protein -
DCC35_RS19700 4470657..4472000 - 1344 WP_137092425.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
DCC35_RS19705 4472145..4473608 + 1464 WP_137092426.1 DASS family sodium-coupled anion symporter -
DCC35_RS19710 4473717..4474013 - 297 WP_137092427.1 HigA family addiction module antidote protein Antitoxin
DCC35_RS19715 4474016..4474297 - 282 WP_137092428.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCC35_RS19720 4474437..4475333 - 897 WP_137092429.1 carboxypeptidase-like regulatory domain-containing protein -
DCC35_RS19725 4475438..4476097 - 660 WP_137092430.1 hypothetical protein -
DCC35_RS19730 4476517..4478856 - 2340 WP_137092431.1 TonB-dependent receptor family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11153.87 Da        Isoelectric Point: 10.3716

>T104378 WP_137092428.1 NZ_CP028923:c4474297-4474016 [Roseivirga pacifica]
MIKTFGDKETEKVFDGIRSKKLPEDIQRIGRRKLRMINNSFSINDLKIPPANRLEKLSGDLKDYHSIRINKQWRIIFKWE
NNDAFYVSIVDYH

Download         Length: 282 bp

>T104378 NZ_CP028923:c4474297-4474016 [Roseivirga pacifica]
TTGATAAAGACATTTGGAGATAAAGAAACTGAGAAGGTCTTTGATGGAATAAGATCAAAAAAACTTCCAGAGGACATTCA
AAGAATCGGCAGACGTAAATTGAGAATGATAAACAACTCATTTTCAATAAATGATTTAAAAATTCCTCCTGCTAATAGAT
TAGAAAAACTATCAGGTGATCTTAAAGATTATCATAGTATCAGAATAAATAAGCAGTGGAGAATAATTTTCAAATGGGAA
AATAACGATGCTTTTTATGTATCAATTGTTGATTATCATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11490.07 Da        Isoelectric Point: 6.4765

>AT104378 WP_137092427.1 NZ_CP028923:c4474013-4473717 [Roseivirga pacifica]
MEKLPNIHPGEVLKEEFLEPLNISAYRLSKETFIPQTRISEIIHGRRRITADTALRFSKFFGTSAKFWMGLQDDFDLEEQ
KEKSKQEIQDIKNYSNVA

Download         Length: 297 bp

>AT104378 NZ_CP028923:c4474013-4473717 [Roseivirga pacifica]
ATGGAAAAACTACCTAACATACATCCTGGAGAAGTTCTAAAGGAAGAATTTTTAGAGCCTTTAAACATAAGTGCATATAG
ATTATCAAAGGAGACTTTTATTCCGCAAACAAGAATAAGTGAAATTATTCATGGCAGAAGAAGAATCACTGCCGATACTG
CACTAAGGTTTTCAAAGTTTTTTGGGACCTCAGCTAAATTCTGGATGGGGTTACAGGACGATTTTGATCTAGAAGAACAA
AAAGAGAAATCAAAACAAGAAATACAGGACATTAAAAATTATAGTAACGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References