Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2930542..2931122 Replicon chromosome
Accession NZ_CP028923
Organism Roseivirga pacifica strain 9dcg1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag DCC35_RS12765 Protein ID WP_137091172.1
Coordinates 2930542..2930823 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DCC35_RS12770 Protein ID WP_137091173.1
Coordinates 2930826..2931122 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCC35_RS12735 2925677..2926270 + 594 WP_137091166.1 HEAT repeat domain-containing protein -
DCC35_RS12740 2926340..2926834 + 495 WP_137091167.1 hypothetical protein -
DCC35_RS12745 2927306..2928304 + 999 WP_137091168.1 hypothetical protein -
DCC35_RS12750 2928522..2928968 + 447 WP_137091169.1 hypothetical protein -
DCC35_RS12755 2929126..2929578 + 453 WP_137091170.1 hypothetical protein -
DCC35_RS12760 2929697..2930353 + 657 WP_137091171.1 hypothetical protein -
DCC35_RS12765 2930542..2930823 + 282 WP_137091172.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCC35_RS12770 2930826..2931122 + 297 WP_137091173.1 HigA family addiction module antidote protein Antitoxin
DCC35_RS12775 2931271..2931570 + 300 WP_137091174.1 hypothetical protein -
DCC35_RS20715 2931551..2931715 + 165 WP_175402816.1 hypothetical protein -
DCC35_RS12780 2931763..2932911 + 1149 WP_137091175.1 hypothetical protein -
DCC35_RS12785 2933044..2933481 + 438 WP_137091176.1 DUF4274 domain-containing protein -
DCC35_RS12790 2933553..2933993 + 441 WP_137091177.1 hypothetical protein -
DCC35_RS12795 2934096..2934884 + 789 WP_137091178.1 hypothetical protein -
DCC35_RS12800 2935061..2935432 + 372 WP_137091179.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11119.77 Da        Isoelectric Point: 10.3568

>T104375 WP_137091172.1 NZ_CP028923:2930542-2930823 [Roseivirga pacifica]
MIKTFGDKETEKVFDGVRSKKLPEDIQRIGRRKLRMINNSFSINDLRIPPANKLEKLSGDLKDYHSIRINKQWRIIFRWE
NNDAFDVSIVDYH

Download         Length: 282 bp

>T104375 NZ_CP028923:2930542-2930823 [Roseivirga pacifica]
TTGATAAAGACATTTGGAGATAAAGAAACTGAGAAAGTCTTTGATGGAGTAAGATCAAAAAAACTTCCAGAGGACATTCA
AAGAATCGGCAGACGTAAGCTAAGAATGATTAACAACTCATTTTCAATAAATGATTTAAGAATTCCTCCTGCTAACAAAT
TAGAAAAACTATCTGGTGATCTTAAAGATTATCATAGTATTAGAATTAATAAGCAGTGGAGAATAATTTTCAGATGGGAA
AACAATGATGCTTTTGATGTTTCAATTGTTGATTATCATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11489.13 Da        Isoelectric Point: 8.5253

>AT104375 WP_137091173.1 NZ_CP028923:2930826-2931122 [Roseivirga pacifica]
MKKLPNIHPGEVLKEEFLEPLNISAYRLSKETFIPQTRISEIIHGRRRITADTALRFSKFFGTSAKFWMGLQDDFDLEEQ
KEKSKQEIQDIKNYSNVA

Download         Length: 297 bp

>AT104375 NZ_CP028923:2930826-2931122 [Roseivirga pacifica]
ATGAAAAAGCTACCTAATATACATCCTGGAGAAGTTCTTAAAGAAGAATTTTTAGAGCCTTTAAATATAAGTGCATATAG
ATTATCAAAGGAAACTTTTATTCCTCAGACAAGAATAAGTGAAATTATTCATGGTAGAAGAAGAATCACTGCTGATACTG
CACTAAGGTTTTCAAAGTTTTTTGGGACCTCAGCTAAATTCTGGATGGGGTTACAGGACGATTTTGATCTAGAAGAACAA
AAAGAGAAATCAAAACAAGAAATACAGGACATTAAAAATTATAGTAACGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References