Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1531048..1531643 Replicon chromosome
Accession NZ_CP028917
Organism Pseudomonas aeruginosa strain JB2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C5B40_RS07255 Protein ID WP_071535843.1
Coordinates 1531048..1531326 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C5B40_RS07260 Protein ID WP_024947077.1
Coordinates 1531338..1531643 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B40_RS07235 1526474..1527712 + 1239 WP_023092962.1 C69 family dipeptidase -
C5B40_RS07240 1527774..1528421 + 648 WP_003095021.1 carbonate dehydratase -
C5B40_RS07245 1528491..1530719 - 2229 WP_021264080.1 TonB-dependent receptor -
C5B40_RS07255 1531048..1531326 + 279 WP_071535843.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C5B40_RS07260 1531338..1531643 + 306 WP_024947077.1 HigA family addiction module antidote protein Antitoxin
C5B40_RS32965 1531985..1532797 - 813 WP_071550097.1 hypothetical protein -
C5B40_RS07270 1532859..1533191 - 333 WP_024947075.1 hypothetical protein -
C5B40_RS07280 1533698..1535584 - 1887 WP_071550095.1 putative DNA binding domain-containing protein -
C5B40_RS07290 1536359..1536631 + 273 WP_003115921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10674.25 Da        Isoelectric Point: 7.8937

>T104366 WP_071535843.1 NZ_CP028917:1531048-1531326 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T104366 NZ_CP028917:1531048-1531326 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGTGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11244.76 Da        Isoelectric Point: 4.6081

>AT104366 WP_024947077.1 NZ_CP028917:1531338-1531643 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLT
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT104366 NZ_CP028917:1531338-1531643 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTACGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAACA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References