Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 34336..34936 Replicon chromosome
Accession NZ_CP028901
Organism Algicoccus marinus strain HZ20

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag DBV39_RS00245 Protein ID WP_108619839.1
Coordinates 34655..34936 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DBV39_RS00240 Protein ID WP_108619838.1
Coordinates 34336..34641 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBV39_RS00220 29460..30518 + 1059 WP_108619834.1 hypothetical protein -
DBV39_RS00225 30650..31270 - 621 WP_108619835.1 hypothetical protein -
DBV39_RS00230 32198..32665 - 468 WP_108619836.1 hypothetical protein -
DBV39_RS00235 32669..33775 - 1107 WP_108619837.1 DUF262 domain-containing protein -
DBV39_RS19310 33911..34048 - 138 WP_159078691.1 hypothetical protein -
DBV39_RS00240 34336..34641 - 306 WP_108619838.1 HigA family addiction module antidote protein Antitoxin
DBV39_RS00245 34655..34936 - 282 WP_108619839.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBV39_RS00250 35317..35637 - 321 WP_108619840.1 DNA-binding transcriptional regulator -
DBV39_RS00255 35713..35979 - 267 WP_193853060.1 type II toxin-antitoxin system RelE/ParE family toxin -
DBV39_RS00260 36530..36871 + 342 WP_108619841.1 DUF1778 domain-containing protein -
DBV39_RS00265 37381..38358 + 978 WP_108619842.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(22-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-91)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10919.35 Da        Isoelectric Point: 7.1892

>T104358 WP_108619839.1 NZ_CP028901:c34936-34655 [Algicoccus marinus]
MTIRSFQCADTQALYEGRHPRRFCQFQAVAQRKLQMLDDAVDLRDLRSPPGNRLEQLKGDRTGQHSIRLNDQWRICFIWG
ESGPECVEIVDYH

Download         Length: 282 bp

>T104358 NZ_CP028901:c34936-34655 [Algicoccus marinus]
ATGACGATACGCTCATTTCAGTGCGCTGATACACAGGCGCTCTATGAAGGCAGGCACCCTAGGCGATTTTGCCAGTTCCA
AGCAGTTGCTCAGCGCAAATTGCAAATGCTTGACGATGCAGTTGATCTTCGCGACTTGCGGTCACCTCCGGGCAACAGGT
TGGAACAACTCAAGGGAGATCGCACCGGACAACACAGCATCCGGCTCAATGACCAGTGGCGGATTTGTTTCATTTGGGGC
GAATCCGGTCCGGAATGTGTCGAAATTGTCGACTATCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11614.34 Da        Isoelectric Point: 8.6746

>AT104358 WP_108619838.1 NZ_CP028901:c34641-34336 [Algicoccus marinus]
MTKNKIRPVHPGEILREEYLAPLGMSAHALAMALHVPAPRINDIVRERRSVTPDTALRLARFFDTTAEFWLNLQSSYDLK
RAEHENGQLIWQEIRPFAHAA

Download         Length: 306 bp

>AT104358 NZ_CP028901:c34641-34336 [Algicoccus marinus]
ATGACCAAGAACAAAATACGTCCAGTTCACCCAGGCGAAATTCTGCGAGAGGAGTATCTTGCGCCCCTGGGCATGTCAGC
TCATGCATTAGCCATGGCGTTGCACGTACCTGCTCCGCGAATTAACGATATCGTTCGCGAACGCAGGTCCGTAACGCCAG
ATACCGCACTAAGGCTTGCGCGATTTTTCGACACTACGGCAGAGTTTTGGCTTAACCTGCAAAGCTCTTATGACCTAAAG
CGGGCTGAACATGAAAACGGCCAACTGATTTGGCAAGAAATCCGGCCATTTGCGCATGCTGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References