Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2883016..2883352 Replicon chromosome
Accession NZ_CP028835
Organism Enterococcus faecalis strain FC

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag C9432_RS14745 Protein ID WP_002396786.1
Coordinates 2883016..2883159 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2883303..2883352 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9432_RS14720 2878673..2879305 - 633 WP_002358972.1 RloB family protein -
C9432_RS14725 2879314..2880609 - 1296 WP_010815865.1 AAA family ATPase -
C9432_RS14740 2881071..2882686 + 1616 Protein_2709 phosphatase PAP2/LCP family protein -
C9432_RS14745 2883016..2883159 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 2883303..2883352 + 50 - - Antitoxin
C9432_RS14750 2883354..2887064 - 3711 WP_175400173.1 WxL domain-containing protein -
C9432_RS14755 2887307..2888044 - 738 WP_175400172.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T104273 WP_002396786.1 NZ_CP028835:2883016-2883159 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T104273 NZ_CP028835:2883016-2883159 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 50 bp

>AT104273 NZ_CP028835:2883303-2883352 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References