Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 13609..14266 Replicon plasmid pCMY2_085072
Accession NZ_CP028804
Organism Klebsiella pneumoniae strain WCHKP7E2

Toxin (Protein)


Gene name higB Uniprot ID U3PDC3
Locus tag B7D49_RS00290 Protein ID WP_000270043.1
Coordinates 13916..14266 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B7D49_RS00285 Protein ID WP_000124640.1
Coordinates 13609..13911 (-) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D49_RS00235 9234..9662 + 429 WP_000591074.1 hypothetical protein -
B7D49_RS00240 9719..10078 + 360 WP_000422768.1 hypothetical protein -
B7D49_RS00245 10078..10524 + 447 WP_000919345.1 Fe3+-siderophore ABC transporter permease -
B7D49_RS00250 10521..11039 + 519 WP_094620540.1 nitrite reductase -
B7D49_RS00255 11039..11269 + 231 WP_000972663.1 hypothetical protein -
B7D49_RS00260 11256..12113 + 858 WP_001167032.1 hypothetical protein -
B7D49_RS00265 12139..12327 + 189 WP_001270411.1 hypothetical protein -
B7D49_RS00270 12344..12871 + 528 WP_001236377.1 thermonuclease family protein -
B7D49_RS00275 12929..13201 + 273 WP_001043047.1 HU family DNA-binding protein -
B7D49_RS00280 13289..13582 + 294 WP_001239997.1 chromosome segregation protein ParM -
B7D49_RS00285 13609..13911 - 303 WP_000124640.1 XRE family transcriptional regulator Antitoxin
B7D49_RS00290 13916..14266 - 351 WP_000270043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7D49_RS00295 14429..14977 + 549 WP_001061574.1 transcriptional regulator -
B7D49_RS00300 15067..15318 + 252 WP_000333619.1 hypothetical protein -
B7D49_RS00305 15318..15512 + 195 WP_000343597.1 hypothetical protein -
B7D49_RS00310 15523..15894 + 372 WP_000516916.1 hypothetical protein -
B7D49_RS00315 15887..16357 + 471 WP_001281821.1 hypothetical protein -
B7D49_RS00320 16372..16713 - 342 WP_001326176.1 hypothetical protein -
B7D49_RS00325 16831..17292 + 462 WP_000286591.1 DUF1643 domain-containing protein -
B7D49_RS00330 17295..17792 + 498 WP_000062185.1 hypothetical protein -
B7D49_RS00335 18007..18711 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
B7D49_RS00340 18776..18955 - 180 Protein_35 ArsR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaCMY-2 / dfrA12 / aadA2 / qacE / sul1 / mph(A) / aph(3')-Ia / aac(3)-IIa / erm(B) - 1..323934 323934


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-106)

Antitoxin

(33-79)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 13328.21 Da        Isoelectric Point: 5.2421

>T104204 WP_000270043.1 NZ_CP028804:c14266-13916 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE

Download         Length: 351 bp

>T104204 NZ_CP028804:c14266-13916 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11006.73 Da        Isoelectric Point: 7.2036

>AT104204 WP_000124640.1 NZ_CP028804:c13911-13609 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV

Download         Length: 303 bp

>AT104204 NZ_CP028804:c13911-13609 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7G8AFB9


Antitoxin

Source ID Structure

References