Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4196972..4197230 Replicon chromosome
Accession NZ_CP028770
Organism Escherichia coli strain A4

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AOY55_RS20235 Protein ID WP_000809168.1
Coordinates 4197078..4197230 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4196972..4197029 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY55_RS20220 4192801..4194060 - 1260 WP_000494929.1 hypothetical protein -
AOY55_RS20225 4194189..4195682 - 1494 WP_001350365.1 sulfatase-like hydrolase/transferase -
AOY55_RS20230 4195702..4196463 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4196972..4197029 - 58 - - Antitoxin
AOY55_RS20235 4197078..4197230 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
AOY55_RS20240 4197335..4198465 - 1131 WP_001118464.1 molecular chaperone DnaJ -
AOY55_RS20245 4198554..4200470 - 1917 WP_000516135.1 molecular chaperone DnaK -
AOY55_RS20250 4200842..4201246 + 405 WP_000843692.1 DUF2541 family protein -
AOY55_RS20255 4201272..4201985 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T104053 WP_000809168.1 NZ_CP028770:4197078-4197230 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T104053 NZ_CP028770:4197078-4197230 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT104053 NZ_CP028770:c4197029-4196972 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References