Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1223476..1224203 Replicon chromosome
Accession NZ_CP028768
Organism Escherichia coli strain A6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AOY57_RS06125 Protein ID WP_016233494.1
Coordinates 1223476..1223787 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AOY57_RS06130 Protein ID WP_000126294.1
Coordinates 1223784..1224203 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY57_RS06100 (1219412) 1219412..1221121 + 1710 WP_001288134.1 formate hydrogenlyase subunit HycE -
AOY57_RS06105 (1221131) 1221131..1221673 + 543 WP_000493797.1 formate hydrogenlyase subunit HycF -
AOY57_RS06110 (1221673) 1221673..1222440 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
AOY57_RS06115 (1222437) 1222437..1222847 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
AOY57_RS06120 (1222840) 1222840..1223310 + 471 WP_000132959.1 hydrogenase maturation peptidase HycI -
AOY57_RS06125 (1223476) 1223476..1223787 + 312 WP_016233494.1 type II toxin-antitoxin system HigB family toxin Toxin
AOY57_RS06130 (1223784) 1223784..1224203 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
AOY57_RS06135 (1224295) 1224295..1224723 - 429 WP_000536064.1 hypothetical protein -
AOY57_RS06140 (1225107) 1225107..1225635 + 529 Protein_1209 electron transport protein HydN -
AOY57_RS06145 (1225788) 1225788..1228040 + 2253 WP_201478671.1 carbamoyltransferase HypF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12453.25 Da        Isoelectric Point: 9.7075

>T103987 WP_016233494.1 NZ_CP028768:1223476-1223787 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNKLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T103987 NZ_CP028768:1223476-1223787 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAAGCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT103987 WP_000126294.1 NZ_CP028768:1223784-1224203 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT103987 NZ_CP028768:1223784-1224203 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References