Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4142304..4142562 Replicon chromosome
Accession NZ_CP028764
Organism Escherichia coli strain A10

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AOY63_RS19820 Protein ID WP_000809168.1
Coordinates 4142410..4142562 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4142304..4142361 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY63_RS19805 4138696..4139655 + 960 WP_000871674.1 hypothetical protein -
AOY63_RS19810 4139693..4140592 - 900 WP_001300855.1 transcriptional activator NhaR -
AOY63_RS19815 4140658..4141824 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4142304..4142361 - 58 - - Antitoxin
AOY63_RS19820 4142410..4142562 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
AOY63_RS19825 4142666..4143796 - 1131 WP_001118454.1 molecular chaperone DnaJ -
AOY63_RS19830 4143885..4145801 - 1917 WP_000516135.1 molecular chaperone DnaK -
AOY63_RS19835 4146177..4146581 + 405 WP_000843584.1 DUF2541 family protein -
AOY63_RS19840 4146607..4147320 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T103905 WP_000809168.1 NZ_CP028764:4142410-4142562 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T103905 NZ_CP028764:4142410-4142562 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT103905 NZ_CP028764:c4142361-4142304 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References