Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 3834168..3834862 | Replicon | chromosome |
| Accession | NZ_CP028764 | ||
| Organism | Escherichia coli strain A10 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | V0YKG6 |
| Locus tag | AOY63_RS18370 | Protein ID | WP_001263485.1 |
| Coordinates | 3834168..3834566 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1QAE3 |
| Locus tag | AOY63_RS18375 | Protein ID | WP_000554758.1 |
| Coordinates | 3834569..3834862 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (3829997) | 3829997..3830077 | - | 81 | NuclAT_12 | - | - |
| - (3829997) | 3829997..3830077 | - | 81 | NuclAT_12 | - | - |
| - (3829997) | 3829997..3830077 | - | 81 | NuclAT_12 | - | - |
| - (3829997) | 3829997..3830077 | - | 81 | NuclAT_12 | - | - |
| AOY63_RS18340 (3829337) | 3829337..3830581 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
| AOY63_RS18345 (3830673) | 3830673..3831131 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| AOY63_RS18350 (3831392) | 3831392..3832849 | + | 1458 | WP_001293009.1 | cytosol nonspecific dipeptidase | - |
| AOY63_RS18355 (3832906) | 3832906..3833258 | - | 353 | Protein_3606 | peptide chain release factor H | - |
| AOY63_RS18360 (3833254) | 3833254..3833460 | - | 207 | Protein_3607 | RtcB family protein | - |
| AOY63_RS18365 (3833706) | 3833706..3834158 | - | 453 | WP_001059899.1 | GNAT family N-acetyltransferase | - |
| AOY63_RS18370 (3834168) | 3834168..3834566 | - | 399 | WP_001263485.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| AOY63_RS18375 (3834569) | 3834569..3834862 | - | 294 | WP_000554758.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| AOY63_RS18380 (3834914) | 3834914..3835969 | - | 1056 | WP_001226177.1 | DNA polymerase IV | - |
| AOY63_RS18385 (3836040) | 3836040..3836963 | - | 924 | WP_001232557.1 | putative lateral flagellar export/assembly protein LafU | - |
| AOY63_RS18390 (3836966) | 3836966..3837829 | - | 864 | WP_001169519.1 | flagellar motor stator protein MotA | - |
| AOY63_RS18395 (3837842) | 3837842..3838561 | - | 720 | WP_000938738.1 | FliA/WhiG family RNA polymerase sigma factor | - |
| AOY63_RS18400 (3838581) | 3838581..3839048 | - | 468 | WP_000725257.1 | flagellar basal body-associated FliL family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15418.84 Da Isoelectric Point: 7.3840
>T103903 WP_001263485.1 NZ_CP028764:c3834566-3834168 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGILPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLCQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGILPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLCQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T103903 NZ_CP028764:c3834566-3834168 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGTGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGTGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.76 Da Isoelectric Point: 5.2170
>AT103903 WP_000554758.1 NZ_CP028764:c3834862-3834569 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT103903 NZ_CP028764:c3834862-3834569 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|