Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4429821..4430078 Replicon chromosome
Accession NZ_CP028761
Organism Escherichia coli strain A13

Toxin (Protein)


Gene name hokA Uniprot ID S1E8G5
Locus tag AOY66_RS21260 Protein ID WP_001135732.1
Coordinates 4429821..4429973 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 4430030..4430078 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY66_RS21230 4425919..4426578 + 660 WP_000747625.1 OmpA family lipoprotein -
AOY66_RS21235 4426682..4427656 + 975 WP_000805027.1 glyoxylate/hydroxypyruvate reductase GhrB -
AOY66_RS21240 4427706..4428416 - 711 WP_000190516.1 DUF3053 domain-containing protein -
AOY66_RS21245 4428850..4429140 + 291 WP_201475048.1 HTH-type transcriptional regulator -
AOY66_RS21250 4429421..4429633 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
AOY66_RS21255 4429773..4429844 + 72 WP_212734239.1 hypothetical protein -
AOY66_RS21260 4429821..4429973 - 153 WP_001135732.1 type I toxin-antitoxin system toxin HokA Toxin
- 4430030..4430078 + 49 - - Antitoxin
AOY66_RS21265 4430296..4432365 - 2070 WP_001291786.1 glycine--tRNA ligase subunit beta -
AOY66_RS21270 4432375..4433286 - 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
AOY66_RS21275 4433381..4433689 - 309 WP_000980157.1 YsaB family lipoprotein -
AOY66_RS21280 4433864..4434859 + 996 WP_001182669.1 O-acetyltransferase WecH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5998.28 Da        Isoelectric Point: 7.7169

>T103836 WP_001135732.1 NZ_CP028761:c4429973-4429821 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Download         Length: 153 bp

>T103836 NZ_CP028761:c4429973-4429821 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGAGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin


Download         Length: 49 bp

>AT103836 NZ_CP028761:4430030-4430078 [Escherichia coli]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1E8G5

Antitoxin

Download structure file

References