Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 799960..800218 Replicon chromosome
Accession NZ_CP028761
Organism Escherichia coli strain A13

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AOY66_RS03785 Protein ID WP_000809168.1
Coordinates 799960..800112 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 800161..800218 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY66_RS03765 795205..795918 - 714 WP_001102393.1 acidic protein MsyB -
AOY66_RS03770 795944..796348 - 405 WP_000843689.1 DUF2541 family protein -
AOY66_RS03775 796720..798636 + 1917 WP_000516135.1 molecular chaperone DnaK -
AOY66_RS03780 798725..799855 + 1131 WP_001118464.1 molecular chaperone DnaJ -
AOY66_RS03785 799960..800112 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 800161..800218 + 58 - - Antitoxin
AOY66_RS03790 800727..801488 + 762 WP_001274832.1 outer membrane protein OmpK -
AOY66_RS03795 801509..803008 + 1500 WP_240775818.1 sulfatase-like hydrolase/transferase -
AOY66_RS03800 803132..804392 + 1261 Protein_724 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T103810 WP_000809168.1 NZ_CP028761:c800112-799960 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T103810 NZ_CP028761:c800112-799960 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT103810 NZ_CP028761:800161-800218 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References