Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 2224969..2225340 | Replicon | chromosome |
| Accession | NZ_CP028760 | ||
| Organism | Escherichia coli strain A14 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
| Locus tag | AOY67_RS10895 | Protein ID | WP_001443846.1 |
| Coordinates | 2225191..2225340 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 2224969..2225147 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY67_RS23355 (2220721) | 2220721..2220894 | + | 174 | WP_001296046.1 | protein YnaL | - |
| AOY67_RS10870 (2220924) | 2220924..2222297 | + | 1374 | WP_000123737.1 | ATP-dependent RNA helicase DbpA | - |
| AOY67_RS10875 (2222426) | 2222426..2223361 | - | 936 | WP_001614527.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| AOY67_RS10880 (2223413) | 2223413..2224648 | - | 1236 | WP_000040839.1 | site-specific integrase | - |
| AOY67_RS10885 (2224650) | 2224650..2224865 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (2224969) | 2224969..2225147 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2224969) | 2224969..2225147 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2224969) | 2224969..2225147 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2224969) | 2224969..2225147 | + | 179 | NuclAT_0 | - | Antitoxin |
| AOY67_RS10890 (2224965) | 2224965..2225153 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| AOY67_RS10895 (2225191) | 2225191..2225340 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| AOY67_RS10900 (2225396) | 2225396..2226205 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
| AOY67_RS10905 (2226198) | 2226198..2228798 | - | 2601 | WP_000105140.1 | exodeoxyribonuclease VIII | - |
| AOY67_RS10910 (2228900) | 2228900..2229175 | - | 276 | WP_001344816.1 | hypothetical protein | - |
| AOY67_RS10915 (2229250) | 2229250..2229420 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| AOY67_RS10920 (2229420) | 2229420..2229641 | - | 222 | WP_000560223.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2216154..2245881 | 29727 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T103785 WP_001443846.1 NZ_CP028760:c2225340-2225191 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T103785 NZ_CP028760:c2225340-2225191 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
Antitoxin
Download Length: 179 bp
>AT103785 NZ_CP028760:2224969-2225147 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
