Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 751636..752329 Replicon chromosome
Accession NZ_CP028752
Organism Escherichia coli strain A23

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag AOY76_RS03680 Protein ID WP_000415584.1
Coordinates 751636..751932 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag AOY76_RS03685 Protein ID WP_000650107.1
Coordinates 751934..752329 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY76_RS03645 (746725) 746725..747039 - 315 WP_000958598.1 putative quinol monooxygenase -
AOY76_RS03650 (747070) 747070..747651 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
AOY76_RS03655 (747970) 747970..748302 + 333 WP_000917684.1 DUF2645 family protein -
AOY76_RS03660 (748348) 748348..749697 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
AOY76_RS03665 (749694) 749694..750353 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
AOY76_RS03670 (750486) 750486..750896 + 411 WP_112032700.1 OB fold stress tolerance protein YgiW -
AOY76_RS03675 (750949) 750949..751431 + 483 WP_000183505.1 GyrI-like domain-containing protein -
AOY76_RS03680 (751636) 751636..751932 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
AOY76_RS03685 (751934) 751934..752329 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
AOY76_RS03690 (752462) 752462..754069 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
AOY76_RS03695 (754207) 754207..756465 + 2259 WP_112032699.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T103584 WP_000415584.1 NZ_CP028752:751636-751932 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T103584 NZ_CP028752:751636-751932 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT103584 WP_000650107.1 NZ_CP028752:751934-752329 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT103584 NZ_CP028752:751934-752329 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References