Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 977550..977808 Replicon chromosome
Accession NZ_CP028751
Organism Escherichia coli strain A24

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AOY77_RS04825 Protein ID WP_000809168.1
Coordinates 977550..977702 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 977751..977808 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY77_RS04805 972795..973508 - 714 WP_001102393.1 acidic protein MsyB -
AOY77_RS04810 973534..973938 - 405 WP_000843689.1 DUF2541 family protein -
AOY77_RS04815 974310..976226 + 1917 WP_000516135.1 molecular chaperone DnaK -
AOY77_RS04820 976315..977445 + 1131 WP_001118464.1 molecular chaperone DnaJ -
AOY77_RS04825 977550..977702 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 977751..977808 + 58 - - Antitoxin
AOY77_RS04830 978317..979078 + 762 WP_001274828.1 outer membrane protein OmpK -
AOY77_RS04835 979098..980591 + 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
AOY77_RS04840 980720..981979 + 1260 WP_000494927.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T103559 WP_000809168.1 NZ_CP028751:c977702-977550 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T103559 NZ_CP028751:c977702-977550 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT103559 NZ_CP028751:977751-977808 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References