Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
Location | 4335697..4337015 | Replicon | chromosome |
Accession | NZ_CP028750 | ||
Organism | Escherichia coli strain A25 |
Toxin (Protein)
Gene name | HipT | Uniprot ID | B7UL96 |
Locus tag | AOY78_RS21170 | Protein ID | WP_001262465.1 |
Coordinates | 4335697..4336704 (-) | Length | 336 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | B7UL97 |
Locus tag | AOY78_RS21175 | Protein ID | WP_001346664.1 |
Coordinates | 4336704..4337015 (-) | Length | 104 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AOY78_RS21145 (4331390) | 4331390..4331581 | + | 192 | WP_000988310.1 | cellulose biosynthesis protein BcsF | - |
AOY78_RS21150 (4331578) | 4331578..4333257 | + | 1680 | WP_000191555.1 | cellulose biosynthesis protein BcsG | - |
AOY78_RS21155 (4333343) | 4333343..4333450 | - | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
- (4333499) | 4333499..4333564 | + | 66 | NuclAT_18 | - | - |
- (4333499) | 4333499..4333564 | + | 66 | NuclAT_18 | - | - |
- (4333499) | 4333499..4333564 | + | 66 | NuclAT_18 | - | - |
- (4333499) | 4333499..4333564 | + | 66 | NuclAT_18 | - | - |
- (4333499) | 4333499..4333564 | + | 66 | NuclAT_24 | - | - |
- (4333499) | 4333499..4333564 | + | 66 | NuclAT_24 | - | - |
- (4333499) | 4333499..4333564 | + | 66 | NuclAT_24 | - | - |
- (4333499) | 4333499..4333564 | + | 66 | NuclAT_24 | - | - |
AOY78_RS21160 (4333826) | 4333826..4333933 | - | 108 | WP_000170747.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
- (4333982) | 4333982..4334047 | + | 66 | NuclAT_19 | - | - |
- (4333982) | 4333982..4334047 | + | 66 | NuclAT_19 | - | - |
- (4333982) | 4333982..4334047 | + | 66 | NuclAT_19 | - | - |
- (4333982) | 4333982..4334047 | + | 66 | NuclAT_19 | - | - |
- (4333982) | 4333982..4334047 | + | 66 | NuclAT_25 | - | - |
- (4333982) | 4333982..4334047 | + | 66 | NuclAT_25 | - | - |
- (4333982) | 4333982..4334047 | + | 66 | NuclAT_25 | - | - |
- (4333982) | 4333982..4334047 | + | 66 | NuclAT_25 | - | - |
AOY78_RS21165 (4334409) | 4334409..4335680 | + | 1272 | WP_001339917.1 | aromatic amino acid transport family protein | - |
AOY78_RS21170 (4335697) | 4335697..4336704 | - | 1008 | WP_001262465.1 | HipA domain-containing protein | Toxin |
AOY78_RS21175 (4336704) | 4336704..4337015 | - | 312 | WP_001346664.1 | HipA N-terminal domain-containing protein | Antitoxin |
AOY78_RS21180 (4337000) | 4337000..4337323 | - | 324 | WP_000563102.1 | helix-turn-helix transcriptional regulator | - |
AOY78_RS21185 (4337548) | 4337548..4338561 | - | 1014 | WP_000103582.1 | dipeptide ABC transporter ATP-binding subunit DppF | - |
AOY78_RS21190 (4338558) | 4338558..4339541 | - | 984 | WP_001196477.1 | dipeptide ABC transporter ATP-binding protein | - |
AOY78_RS21195 (4339552) | 4339552..4340454 | - | 903 | WP_000084677.1 | dipeptide ABC transporter permease DppC | - |
AOY78_RS21200 (4340464) | 4340464..4341483 | - | 1020 | WP_000938855.1 | dipeptide ABC transporter permease DppB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 336 a.a. Molecular weight: 38329.55 Da Isoelectric Point: 5.4135
>T103553 WP_001262465.1 NZ_CP028750:c4336704-4335697 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLNPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLNPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
Download Length: 1008 bp
>T103553 NZ_CP028750:c4336704-4335697 [Escherichia coli]
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGAATCCTCGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGGATGAAGGAGAGTTTCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGTTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATAACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTACAGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGCTTAGTGTACTCCGATGGTTTGACGCCTGCGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTTACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAACTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGAATCCTCGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGGATGAAGGAGAGTTTCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGTTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATAACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTACAGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGCTTAGTGTACTCCGATGGTTTGACGCCTGCGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTTACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAACTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11831.41 Da Isoelectric Point: 6.3215
>AT103553 WP_001346664.1 NZ_CP028750:c4337015-4336704 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAHDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
MHRRVKVLLYGQVVGELSQNDSGFLFQYAHDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
Download Length: 312 bp
>AT103553 NZ_CP028750:c4337015-4336704 [Escherichia coli]
ATGCATCGGCGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTACGCCCACGATTACCACGGACCGGCAATCTCAATCAGTCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGACGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCCATCCAGATTTTACCTTGGGAGGAATAA
ATGCATCGGCGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTACGCCCACGATTACCACGGACCGGCAATCTCAATCAGTCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGACGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCCATCCAGATTTTACCTTGGGAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 7AB4 | |
PDB | 7AB5 | |
PDB | 7AB3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0K5V9L6 |