Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3998564..3999257 Replicon chromosome
Accession NZ_CP028748
Organism Escherichia coli strain A27

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag AOY80_RS19220 Protein ID WP_000415584.1
Coordinates 3998961..3999257 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag AOY80_RS19215 Protein ID WP_000650107.1
Coordinates 3998564..3998959 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY80_RS19205 (3994428) 3994428..3996686 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
AOY80_RS19210 (3996824) 3996824..3998431 - 1608 WP_096933585.1 ABC transporter substrate-binding protein -
AOY80_RS19215 (3998564) 3998564..3998959 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
AOY80_RS19220 (3998961) 3998961..3999257 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
AOY80_RS19225 (3999462) 3999462..3999944 - 483 WP_000183505.1 GyrI-like domain-containing protein -
AOY80_RS19230 (3999997) 3999997..4000389 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
AOY80_RS19235 (4000541) 4000541..4001200 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
AOY80_RS19240 (4001197) 4001197..4002546 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
AOY80_RS19245 (4002592) 4002592..4002924 - 333 WP_000917684.1 DUF2645 family protein -
AOY80_RS19250 (4003243) 4003243..4003824 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
AOY80_RS19255 (4003855) 4003855..4004169 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T103502 WP_000415584.1 NZ_CP028748:c3999257-3998961 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T103502 NZ_CP028748:c3999257-3998961 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT103502 WP_000650107.1 NZ_CP028748:c3998959-3998564 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT103502 NZ_CP028748:c3998959-3998564 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References