Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 818128..818386 Replicon chromosome
Accession NZ_CP028743
Organism Escherichia coli strain A32

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AOY85_RS03895 Protein ID WP_000809168.1
Coordinates 818128..818280 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 818329..818386 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY85_RS03875 813373..814086 - 714 WP_001102393.1 acidic protein MsyB -
AOY85_RS03880 814112..814516 - 405 WP_000843689.1 DUF2541 family protein -
AOY85_RS03885 814888..816804 + 1917 WP_000516135.1 molecular chaperone DnaK -
AOY85_RS03890 816893..818023 + 1131 WP_001118464.1 molecular chaperone DnaJ -
AOY85_RS03895 818128..818280 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 818329..818386 + 58 - - Antitoxin
AOY85_RS03900 818895..819656 + 762 WP_001274832.1 outer membrane protein OmpK -
AOY85_RS03905 819676..821169 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
AOY85_RS03910 821298..822557 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T103356 WP_000809168.1 NZ_CP028743:c818280-818128 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T103356 NZ_CP028743:c818280-818128 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT103356 NZ_CP028743:818329-818386 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References