Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 2158776..2159304 | Replicon | chromosome |
| Accession | NZ_CP028741 | ||
| Organism | Escherichia coli strain A34 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | AOY87_RS10720 | Protein ID | WP_240766088.1 |
| Coordinates | 2159074..2159304 (-) | Length | 77 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AOY87_RS10715 | Protein ID | WP_240766087.1 |
| Coordinates | 2158776..2159084 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY87_RS10665 (2153867) | 2153867..2154055 | - | 189 | WP_240766078.1 | hypothetical protein | - |
| AOY87_RS10670 (2154232) | 2154232..2154813 | - | 582 | WP_240766079.1 | hypothetical protein | - |
| AOY87_RS10675 (2154819) | 2154819..2155001 | - | 183 | WP_240766080.1 | hypothetical protein | - |
| AOY87_RS10680 (2155199) | 2155199..2155399 | - | 201 | WP_240766081.1 | hypothetical protein | - |
| AOY87_RS10685 (2155405) | 2155405..2156094 | - | 690 | WP_240766082.1 | helix-turn-helix domain-containing protein | - |
| AOY87_RS10690 (2156239) | 2156239..2156625 | - | 387 | WP_240766083.1 | helix-turn-helix domain-containing protein | - |
| AOY87_RS10695 (2156722) | 2156722..2156961 | + | 240 | WP_240766084.1 | Cro/CI family transcriptional regulator | - |
| AOY87_RS10700 (2157043) | 2157043..2157333 | - | 291 | WP_240766085.1 | hypothetical protein | - |
| AOY87_RS10705 (2157686) | 2157686..2158567 | + | 882 | WP_240766003.1 | KilA-N domain-containing protein | - |
| AOY87_RS10710 (2158581) | 2158581..2158757 | + | 177 | WP_240766086.1 | DUF4222 domain-containing protein | - |
| AOY87_RS10715 (2158776) | 2158776..2159084 | - | 309 | WP_240766087.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| AOY87_RS10720 (2159074) | 2159074..2159304 | - | 231 | WP_240766088.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AOY87_RS10725 (2159317) | 2159317..2160465 | + | 1149 | WP_240766089.1 | ash family protein | - |
| AOY87_RS10730 (2160462) | 2160462..2160818 | + | 357 | WP_240766090.1 | transcriptional regulator | - |
| AOY87_RS10735 (2160815) | 2160815..2161048 | + | 234 | WP_240766007.1 | hypothetical protein | - |
| AOY87_RS10740 (2161035) | 2161035..2161976 | + | 942 | WP_240766091.1 | DNA-binding protein | - |
| AOY87_RS10745 (2161987) | 2161987..2162865 | + | 879 | WP_240766092.1 | ATP-binding protein | - |
| AOY87_RS10750 (2162862) | 2162862..2164262 | + | 1401 | WP_240766093.1 | replicative DNA helicase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2149578..2199667 | 50089 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 77 a.a. Molecular weight: 8666.19 Da Isoelectric Point: 10.4802
>T103317 WP_240766088.1 NZ_CP028741:c2159304-2159074 [Escherichia coli]
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLKGKRIIMLHSFIKKTQKTPPAELKKAETRMKEVKHDW
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLKGKRIIMLHSFIKKTQKTPPAELKKAETRMKEVKHDW
Download Length: 231 bp
>T103317 NZ_CP028741:c2159304-2159074 [Escherichia coli]
ATGAAGGTATACGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGACGGGCTTTTTGAGCTTCGGATTAAAGG
CAGCGATGGCATTGCCCGCGTTTTTTACTGCACGCTGAAAGGCAAACGCATCATCATGCTGCATAGTTTCATCAAGAAGA
CCCAGAAGACCCCGCCAGCCGAACTCAAAAAAGCCGAAACCAGAATGAAGGAGGTTAAACATGACTGGTAA
ATGAAGGTATACGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGACGGGCTTTTTGAGCTTCGGATTAAAGG
CAGCGATGGCATTGCCCGCGTTTTTTACTGCACGCTGAAAGGCAAACGCATCATCATGCTGCATAGTTTCATCAAGAAGA
CCCAGAAGACCCCGCCAGCCGAACTCAAAAAAGCCGAAACCAGAATGAAGGAGGTTAAACATGACTGGTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11138.88 Da Isoelectric Point: 9.7256
>AT103317 WP_240766087.1 NZ_CP028741:c2159084-2158776 [Escherichia coli]
MTGKRNPPTMTHDEMVAKWMADPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGVSG
PSFATLKKFARATGKKLQIRFV
MTGKRNPPTMTHDEMVAKWMADPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGVSG
PSFATLKKFARATGKKLQIRFV
Download Length: 309 bp
>AT103317 NZ_CP028741:c2159084-2158776 [Escherichia coli]
ATGACTGGTAAACGTAACCCGCCAACCATGACACACGATGAAATGGTGGCTAAATGGATGGCAGATCCAGCATTTAAAGC
AGAATACGACGCCATCGCCGACGAATTTGCACTGCTTGATGAAATGCTGGCCGCACGCAAAGAAGCTGGTCTCACCCAGG
CAGAAGTCGCTGAACGTATGGGTACCAAAGCAACCGCCATTACCAGAATGGAAAGCAATCTCGCATCCGGCGTCAGCGGA
CCATCATTTGCCACACTGAAAAAATTTGCCCGTGCAACAGGGAAAAAACTCCAGATCCGCTTCGTGTAA
ATGACTGGTAAACGTAACCCGCCAACCATGACACACGATGAAATGGTGGCTAAATGGATGGCAGATCCAGCATTTAAAGC
AGAATACGACGCCATCGCCGACGAATTTGCACTGCTTGATGAAATGCTGGCCGCACGCAAAGAAGCTGGTCTCACCCAGG
CAGAAGTCGCTGAACGTATGGGTACCAAAGCAACCGCCATTACCAGAATGGAAAGCAATCTCGCATCCGGCGTCAGCGGA
CCATCATTTGCCACACTGAAAAAATTTGCCCGTGCAACAGGGAAAAAACTCCAGATCCGCTTCGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|