Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 1768379..1768881 | Replicon | chromosome |
Accession | NZ_CP028741 | ||
Organism | Escherichia coli strain A34 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | AOY87_RS08445 | Protein ID | WP_000767829.1 |
Coordinates | 1768627..1768881 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | - |
Locus tag | AOY87_RS08440 | Protein ID | WP_096884122.1 |
Coordinates | 1768379..1768630 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AOY87_RS08415 (1763556) | 1763556..1764623 | - | 1068 | WP_077039640.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
AOY87_RS08420 (1764623) | 1764623..1765693 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
AOY87_RS08425 (1765690) | 1765690..1766994 | - | 1305 | WP_240765925.1 | histidinol dehydrogenase | - |
AOY87_RS08430 (1767000) | 1767000..1767899 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
AOY87_RS08435 (1768045) | 1768045..1768095 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
AOY87_RS08440 (1768379) | 1768379..1768630 | + | 252 | WP_096884122.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
AOY87_RS08445 (1768627) | 1768627..1768881 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
AOY87_RS08450 (1768964) | 1768964..1769788 | + | 825 | WP_000754758.1 | SDR family oxidoreductase | - |
AOY87_RS08455 (1769834) | 1769834..1770763 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
AOY87_RS08460 (1770978) | 1770978..1771040 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
AOY87_RS08465 (1771030) | 1771030..1772388 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
AOY87_RS08470 (1772567) | 1772567..1773625 | + | 1059 | WP_000492305.1 | thiosulfate utilization transporter TsuA/YeeE | - |
AOY87_RS08475 (1773639) | 1773639..1773866 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T103308 WP_000767829.1 NZ_CP028741:1768627-1768881 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T103308 NZ_CP028741:1768627-1768881 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9322.55 Da Isoelectric Point: 4.7954
>AT103308 WP_096884122.1 NZ_CP028741:1768379-1768630 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLQRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLQRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT103308 NZ_CP028741:1768379-1768630 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACAGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACAGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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