Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1890349..1890851 Replicon chromosome
Accession NZ_CP028734
Organism Escherichia coli strain A42

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag AOY95_RS08940 Protein ID WP_045133080.1
Coordinates 1890597..1890851 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag AOY95_RS08935 Protein ID WP_001259255.1
Coordinates 1890349..1890600 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY95_RS08910 (1885527) 1885527..1886594 - 1068 WP_000080115.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
AOY95_RS08915 (1886594) 1886594..1887664 - 1071 WP_045133083.1 histidinol-phosphate transaminase -
AOY95_RS08920 (1887661) 1887661..1888965 - 1305 WP_045133081.1 histidinol dehydrogenase -
AOY95_RS08925 (1888971) 1888971..1889870 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
AOY95_RS08930 (1890016) 1890016..1890066 - 51 WP_001364200.1 his operon leader peptide -
AOY95_RS08935 (1890349) 1890349..1890600 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
AOY95_RS08940 (1890597) 1890597..1890851 + 255 WP_045133080.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
AOY95_RS08945 (1890934) 1890934..1891758 + 825 WP_000754740.1 SDR family oxidoreductase -
AOY95_RS08950 (1891804) 1891804..1892733 + 930 WP_045133079.1 LysR substrate-binding domain-containing protein -
AOY95_RS08955 (1892948) 1892948..1893010 + 63 WP_010723108.1 membrane protein YoeI -
AOY95_RS08960 (1893000) 1893000..1894358 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T103156 WP_045133080.1 NZ_CP028734:1890597-1890851 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEDHRLVYAVTDDLLLIAAC
RYHY

Download         Length: 255 bp

>T103156 NZ_CP028734:1890597-1890851 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACTGATGATTTACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT103156 WP_001259255.1 NZ_CP028734:1890349-1890600 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT103156 NZ_CP028734:1890349-1890600 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References