Detailed information of TA system TA103080

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1311409..1311697
• Replicon: chromosome
• Accession: NZ_CP028724
• Organism: Enterococcus faecalis strain CVM N60443F

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: C7I31_RS06425
• Protein ID: WP_002396786.1
• Coordinates: 1311409..1311552 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1311484..1311697 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7I31_RS06415	1306693..1306845	+	153	WP_073340330.1	putative holin-like toxin	-
-	1306778..1307033	-	256	NuclAT_3	-	-
C7I31_RS06420	1307035..1310814	-	3780	WP_131639191.1	WxL domain-containing protein	-
-	1311155..1311312	-	158	NuclAT_5	-	-
-	1311165..1311298	-	134	NuclAT_11	-	-
C7I31_RS06425	1311409..1311552	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	1311484..1311697	-	214	NuclAT_10	-	Antitoxin
-	1311740..1311789	+	50	NuclAT_14	-	-
C7I31_RS14330	1311790..1314849	-	3060	WP_025190649.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T103080 WP_002396786.1 NZ_CP028724:1311409-1311552 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T103080 NZ_CP028724:1311409-1311552 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 214 bp

>AT103080 NZ_CP028724:c1311697-1311484 [Enterococcus faecalis]
TTGATGGTCTTTTGATGGTCGTTGTGCTATAATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAG
CCGTTTAAGACGGTAGCGATTTTTAGTGATTTATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTC
TTCTTTAACAGCCTCTAGGATTCCGAAGATTAACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin