Detailed information of TA system TA103066

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1228203..1228475
• Replicon: chromosome
• Accession: NZ_CP028724
• Organism: Enterococcus faecalis strain CVM N60443F

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A2P6B8G0
• Locus tag: C7I31_RS06055
• Protein ID: WP_002354873.1
• Coordinates: 1228323..1228475 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1228203..1228390 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7I31_RS06040	1223908..1226652	+	2745	WP_131639179.1	glycoside hydrolase family 65 protein	-
C7I31_RS06045	1226667..1227317	+	651	WP_002367457.1	beta-phosphoglucomutase	-
-	1227372..1227505	+	134	NuclAT_7	-	-
C7I31_RS06050	1227778..1228038	+	261	Protein_1134	hypothetical protein	-
-	1228203..1228349	+	147	NuclAT_13	-	-
-	1228203..1228390	+	188	NuclAT_4	-	Antitoxin
C7I31_RS06055	1228323..1228475	-	153	WP_002354873.1	putative holin-like toxin	Toxin
-	1228579..1228720	+	142	NuclAT_6	-	-
-	1228579..1228722	+	144	NuclAT_12	-	-
C7I31_RS06060	1229219..1229752	+	534	WP_002385180.1	CPBP family intramembrane metalloprotease	-
C7I31_RS06065	1229805..1230776	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
C7I31_RS06070	1230951..1231388	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
C7I31_RS06075	1231521..1232075	-	555	WP_002354869.1	septum formation protein Maf	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5651.89 Da
• Isoelectric Point: 10.9857

>T103066 WP_002354873.1 NZ_CP028724:c1228475-1228323 [Enterococcus faecalis]
VVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 153 bp

>T103066 NZ_CP028724:c1228475-1228323 [Enterococcus faecalis]
GTGGTGCGTATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 188 bp

>AT103066 NZ_CP028724:1228203-1228390 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTACTCAGTCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A2P6B8G0

Antitoxin