Detailed information of TA system TA103060

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1295959..1296206
• Replicon: chromosome
• Accession: NZ_CP028720
• Organism: Enterococcus faecalis strain CVM N48037F

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: C7I32_RS06740
• Protein ID: WP_002386265.1
• Coordinates: 1295959..1296087 (+)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1296032..1296206 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7I32_RS06725	1292421..1292921	-	501	WP_002365352.1	cysteine hydrolase	-
C7I32_RS06730	1293092..1295362	+	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
C7I32_RS16175	1295524..1295653	+	130	Protein_1192	putative holin-like toxin	-
-	1295590..1295777	-	188	NuclAT_5	-	-
-	1295607..1295811	-	205	NuclAT_4	-	-
C7I32_RS06740	1295959..1296087	+	129	WP_002386265.1	hypothetical protein	Toxin
-	1296032..1296206	-	175	NuclAT_6	-	Antitoxin
-	1296036..1296243	-	208	NuclAT_3	-	-
C7I32_RS06745	1296269..1296721	-	453	WP_002359057.1	YueI family protein	-
C7I32_RS06750	1296906..1297853	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
C7I32_RS06755	1297850..1298815	+	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
C7I32_RS06760	1298812..1299567	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
C7I32_RS06765	1299606..1300559	+	954	WP_033626635.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4742.66 Da
• Isoelectric Point: 7.0058

>T103060 WP_002386265.1 NZ_CP028720:1295959-1296087 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 129 bp

>T103060 NZ_CP028720:1295959-1296087 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT103060 NZ_CP028720:c1296206-1296032 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Structures

Antitoxin