Detailed information of TA system TA103050

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1231353..1231795
• Replicon: chromosome
• Accession: NZ_CP028720
• Organism: Enterococcus faecalis strain CVM N48037F

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A2P6B8G0
• Locus tag: C7I32_RS06420
• Protein ID: WP_002354873.1
• Coordinates: 1231643..1231795 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1231353..1231551 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7I32_RS06395	1226619..1228751	+	2133	WP_033626640.1	DNA mismatch repair endonuclease MutL	-
C7I32_RS06400	1228776..1229330	+	555	WP_002354869.1	septum formation protein Maf	-
C7I32_RS06405	1229463..1229900	+	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
C7I32_RS06410	1230075..1231046	+	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
C7I32_RS06415	1231277..1231420	+	144	WP_016619098.1	putative holin-like toxin	-
-	1231353..1231551	-	199	NuclAT_7	-	Antitoxin
-	1231394..1231539	-	146	NuclAT_12	-	-
C7I32_RS06420	1231643..1231795	+	153	WP_002354873.1	putative holin-like toxin	Toxin
-	1231728..1231914	-	187	NuclAT_8	-	-
-	1231769..1231914	-	146	NuclAT_11	-	-
-	1231961..1232096	-	136	NuclAT_13	-	-
-	1231970..1232110	-	141	NuclAT_9	-	-
C7I32_RS06430	1232165..1232815	-	651	WP_002354875.1	beta-phosphoglucomutase	-
C7I32_RS06435	1232830..1235574	-	2745	WP_104857211.1	glycoside hydrolase family 65 protein	-
C7I32_RS06440	1235836..1236549	+	714	WP_002354877.1	trehalose operon repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5651.89 Da
• Isoelectric Point: 10.9857

>T103050 WP_002354873.1 NZ_CP028720:1231643-1231795 [Enterococcus faecalis]
VVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 153 bp

>T103050 NZ_CP028720:1231643-1231795 [Enterococcus faecalis]
GTGGTGCGTATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 199 bp

>AT103050 NZ_CP028720:c1231551-1231353 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAACAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A2P6B8G0

Antitoxin