Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3025942..3026519 Replicon chromosome
Accession NZ_CP028719
Organism Streptomyces sp. endophyte_N2

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag DBA17_RS12960 Protein ID WP_128789975.1
Coordinates 3026262..3026519 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DBA17_RS12955 Protein ID WP_128789974.1
Coordinates 3025942..3026265 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBA17_RS12935 3021187..3022371 + 1185 WP_164932527.1 GNAT family N-acetyltransferase -
DBA17_RS12940 3022682..3023740 + 1059 WP_128789971.1 glycoside hydrolase family 11 protein -
DBA17_RS12945 3023889..3024584 + 696 WP_128789972.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
DBA17_RS12950 3024707..3025855 + 1149 WP_128789973.1 FAD-dependent monooxygenase -
DBA17_RS12955 3025942..3026265 - 324 WP_128789974.1 helix-turn-helix transcriptional regulator Antitoxin
DBA17_RS12960 3026262..3026519 - 258 WP_128789975.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBA17_RS12965 3026695..3028398 + 1704 WP_128789976.1 ABC transporter substrate-binding protein -
DBA17_RS12970 3028403..3029365 + 963 WP_128789977.1 ABC transporter permease -
DBA17_RS12975 3029362..3031317 + 1956 WP_128789978.1 dipeptide/oligopeptide/nickel ABC transporter permease/ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-72)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-90)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9890.04 Da        Isoelectric Point: 4.4179

>T103040 WP_128789975.1 NZ_CP028719:c3026519-3026262 [Streptomyces sp. endophyte_N2]
VEEQWDVYLTAEVDQWLHDLKELRPGSTGRSEVRVLFMFDPWRSAILLTAGDKAGDWGAWYERAIPLAERAYTEYLADRE
KESGK

Download         Length: 258 bp

>T103040 NZ_CP028719:c3026519-3026262 [Streptomyces sp. endophyte_N2]
GTGGAAGAACAGTGGGACGTCTACCTGACCGCCGAGGTGGATCAGTGGCTGCACGATCTCAAGGAGTTGCGTCCCGGCTC
GACGGGACGAAGTGAAGTGCGCGTCCTGTTCATGTTCGACCCCTGGCGCTCCGCGATTCTTCTGACGGCCGGGGACAAGG
CGGGGGACTGGGGTGCCTGGTACGAGCGGGCGATCCCCCTGGCCGAGCGGGCCTATACGGAGTACCTGGCCGATCGGGAG
AAGGAGTCGGGGAAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11659.18 Da        Isoelectric Point: 8.6007

>AT103040 WP_128789974.1 NZ_CP028719:c3026265-3025942 [Streptomyces sp. endophyte_N2]
MSGYTKWSGSGHRERAEELAGGREPFFAGAERLLAEARAWRLVEMRQERGFTQAQVAERMGVSKGRVSQIESGQVSGTEV
VARYVEALGGNLVMVAVFADGELRKVG

Download         Length: 324 bp

>AT103040 NZ_CP028719:c3026265-3025942 [Streptomyces sp. endophyte_N2]
ATGAGCGGATACACCAAGTGGTCCGGAAGCGGTCACCGTGAACGCGCGGAAGAGCTGGCCGGAGGGCGGGAGCCGTTTTT
CGCCGGGGCGGAACGGCTGCTCGCGGAGGCGCGGGCCTGGCGGTTGGTGGAGATGAGGCAGGAGCGGGGCTTCACTCAGG
CTCAGGTCGCCGAGCGCATGGGCGTGAGCAAGGGGCGGGTCTCGCAGATCGAGAGTGGGCAGGTGTCCGGGACGGAGGTC
GTCGCCCGGTACGTCGAGGCGTTGGGCGGAAACCTGGTGATGGTCGCGGTGTTCGCGGACGGGGAACTGCGCAAGGTCGG
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References