Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4029391..4030084 Replicon chromosome
Accession NZ_CP028703
Organism Escherichia coli strain ME8067

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag DBB47_RS20820 Protein ID WP_000415584.1
Coordinates 4029788..4030084 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag DBB47_RS20815 Protein ID WP_000650107.1
Coordinates 4029391..4029786 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBB47_RS20800 4025255..4027513 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
DBB47_RS20805 4027651..4029258 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
DBB47_RS20815 4029391..4029786 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
DBB47_RS20820 4029788..4030084 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
DBB47_RS20825 4030289..4030771 - 483 WP_000183505.1 transcriptional regulator -
DBB47_RS20830 4030824..4031216 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
DBB47_RS20835 4031368..4032027 + 660 WP_001221495.1 two-component system response regulator QseB -
DBB47_RS20840 4032024..4033373 + 1350 WP_108118814.1 two-component system sensor histidine kinase QseC -
DBB47_RS20845 4033419..4033751 - 333 WP_000917684.1 DUF2645 family protein -
DBB47_RS20855 4034070..4034651 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
DBB47_RS20860 4034682..4034996 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T103017 WP_000415584.1 NZ_CP028703:c4030084-4029788 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T103017 NZ_CP028703:c4030084-4029788 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT103017 WP_000650107.1 NZ_CP028703:c4029786-4029391 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT103017 NZ_CP028703:c4029786-4029391 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References