Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3243594..3244389 Replicon chromosome
Accession NZ_CP028698
Organism Escherichia coli strain 106

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C9E35_RS16920 Protein ID WP_000854914.1
Coordinates 3243594..3243968 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag C9E35_RS16925 Protein ID WP_001280954.1
Coordinates 3244015..3244389 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E35_RS16880 3238598..3239089 - 492 WP_001301587.1 DUF1097 domain-containing protein -
C9E35_RS16885 3239191..3239745 - 555 WP_001001917.1 molecular chaperone YcdY -
C9E35_RS16890 3239769..3240506 - 738 WP_000283664.1 zinc-binding phosphatase -
C9E35_RS16895 3240561..3241499 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
C9E35_RS16905 3241970..3242812 - 843 WP_001280481.1 DUF4942 domain-containing protein -
C9E35_RS16910 3242897..3243094 - 198 WP_000839282.1 DUF957 domain-containing protein -
C9E35_RS16915 3243106..3243597 - 492 WP_000976853.1 hypothetical protein -
C9E35_RS16920 3243594..3243968 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C9E35_RS16925 3244015..3244389 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C9E35_RS16930 3244552..3244773 - 222 WP_001220314.1 DUF987 domain-containing protein -
C9E35_RS16935 3244836..3245312 - 477 WP_001186738.1 RadC family protein -
C9E35_RS16940 3245328..3245813 - 486 WP_000214398.1 antirestriction protein -
C9E35_RS16945 3245904..3246722 - 819 WP_001234682.1 DUF945 domain-containing protein -
C9E35_RS16955 3247062..3248132 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
C9E35_RS16960 3248129..3249034 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3234980..3245813 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T102892 WP_000854914.1 NZ_CP028698:c3243968-3243594 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T102892 NZ_CP028698:c3243968-3243594 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT102892 WP_001280954.1 NZ_CP028698:c3244389-3244015 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT102892 NZ_CP028698:c3244389-3244015 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References