Detailed information of TA system TA102856

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2626067..2626438
• Replicon: chromosome
• Accession: NZ_CP028695
• Organism: Escherichia coli strain 107

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: C9E36_RS13380
• Protein ID: WP_001443846.1
• Coordinates: 2626289..2626438 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2626067..2626245 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9E36_RS28385	2621819..2621989	+	171	WP_001625136.1	hypothetical protein	-
C9E36_RS13355	2622022..2623395	+	1374	WP_000123746.1	ATP-dependent RNA helicase DbpA	-
C9E36_RS13360	2623524..2624459	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
C9E36_RS13365	2624511..2625746	-	1236	WP_000040839.1	site-specific integrase	-
C9E36_RS13370	2625748..2625963	-	216	WP_000079604.1	excisionase XisR	-
C9E36_RS13375	2626063..2626251	-	189	WP_001302840.1	DUF1187 family protein	-
-	2626067..2626245	+	179	NuclAT_0	-	Antitoxin
-	2626067..2626245	+	179	NuclAT_0	-	Antitoxin
-	2626067..2626245	+	179	NuclAT_0	-	Antitoxin
-	2626067..2626245	+	179	NuclAT_0	-	Antitoxin
C9E36_RS13380	2626289..2626438	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
C9E36_RS13385	2626494..2627303	-	810	WP_000166313.1	recombination protein RecT	-
C9E36_RS13390	2627296..2629896	-	2601	WP_000105140.1	exodeoxyribonuclease VIII	-
C9E36_RS13395	2629998..2630273	-	276	WP_001344816.1	hypothetical protein	-
C9E36_RS13400	2630348..2630518	-	171	WP_001352098.1	conserved protein, Rac prophage	-
C9E36_RS13405	2630518..2630739	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2624511..2729576	105065

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T102856 WP_001443846.1 NZ_CP028695:c2626438-2626289 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T102856 NZ_CP028695:c2626438-2626289 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT102856 NZ_CP028695:2626067-2626245 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin