Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4786958..4787370 Replicon chromosome
Accession NZ_CP028693
Organism Escherichia coli strain 108

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag C9E37_RS24700 Protein ID WP_000132630.1
Coordinates 4787029..4787370 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4786958..4787034 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E37_RS24690 4783585..4785054 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
C9E37_RS24695 4785054..4786808 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4786958..4787034 - 77 NuclAT_15 - Antitoxin
- 4786958..4787034 - 77 NuclAT_15 - Antitoxin
- 4786958..4787034 - 77 NuclAT_15 - Antitoxin
- 4786958..4787034 - 77 NuclAT_15 - Antitoxin
- 4786958..4787034 - 77 NuclAT_16 - Antitoxin
- 4786958..4787034 - 77 NuclAT_16 - Antitoxin
- 4786958..4787034 - 77 NuclAT_16 - Antitoxin
- 4786958..4787034 - 77 NuclAT_16 - Antitoxin
C9E37_RS24700 4787029..4787370 + 342 WP_000132630.1 endoribonuclease SymE Toxin
C9E37_RS24705 4787417..4788580 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
C9E37_RS24710 4788628..4789509 - 882 WP_001304007.1 DUF262 domain-containing protein -
C9E37_RS24715 4789606..4789770 - 165 WP_000394274.1 DUF1127 domain-containing protein -
C9E37_RS24720 4789947..4791359 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
C9E37_RS28535 4791602..4791802 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4779157..4800390 21233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-71)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T102833 WP_000132630.1 NZ_CP028693:4787029-4787370 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T102833 NZ_CP028693:4787029-4787370 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT102833 NZ_CP028693:c4787034-4786958 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0


Antitoxin

Download structure file

References