Detailed information of TA system TA102586

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2527882..2528107
• Replicon: chromosome
• Accession: NZ_CP028674
• Organism: Escherichia coli strain 115

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: C9E44_RS12915
• Protein ID: WP_000813258.1
• Coordinates: 2527952..2528107 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2527882..2527940 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9E44_RS12865	2522947..2523189	+	243	WP_000747948.1	hypothetical protein	-
C9E44_RS12870	2523173..2523598	+	426	WP_000693878.1	Rha family transcriptional regulator	-
C9E44_RS12875	2523667..2524710	+	1044	WP_001262402.1	hypothetical protein	-
C9E44_RS12880	2524703..2525164	+	462	WP_000139447.1	replication protein	-
C9E44_RS12885	2525198..2525914	+	717	WP_000450627.1	DUF1627 domain-containing protein	-
C9E44_RS12890	2525947..2526228	+	282	WP_000603384.1	DNA-binding protein	-
C9E44_RS12895	2526225..2526452	+	228	WP_000699809.1	hypothetical protein	-
C9E44_RS12900	2526445..2526756	+	312	WP_001289673.1	hypothetical protein	-
C9E44_RS12905	2526884..2527102	+	219	WP_000683609.1	DUF4014 family protein	-
C9E44_RS12910	2527104..2527661	+	558	WP_000104474.1	DUF551 domain-containing protein	-
-	2527882..2527940	-	59	-	-	Antitoxin
C9E44_RS12915	2527952..2528107	+	156	WP_000813258.1	type I toxin-antitoxin system Hok family toxin	Toxin
C9E44_RS12920	2528227..2528571	+	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
C9E44_RS12925	2528693..2528965	+	273	WP_000191872.1	hypothetical protein	-
C9E44_RS12930	2528967..2530016	+	1050	WP_001265229.1	DUF968 domain-containing protein	-
C9E44_RS12935	2530029..2530334	+	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
C9E44_RS12940	2530397..2530951	+	555	WP_000640035.1	DUF1133 family protein	-
C9E44_RS12945	2531176..2531373	+	198	WP_000917763.1	hypothetical protein	-
C9E44_RS12950	2531509..2532222	+	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
C9E44_RS12965	2532673..2533104	+	432	WP_001302123.1	tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleA/espI / espM1	2449609..2565221	115612

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T102586 WP_000813258.1 NZ_CP028674:2527952-2528107 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T102586 NZ_CP028674:2527952-2528107 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT102586 NZ_CP028674:c2527940-2527882 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin