Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4381803..4382342 Replicon chromosome
Accession NZ_CP028671
Organism Escherichia coli strain 116

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag C9E45_RS22665 Protein ID WP_001303998.1
Coordinates 4382082..4382342 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag C9E45_RS22660 Protein ID WP_000729705.1
Coordinates 4381803..4382063 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E45_RS22640 4377557..4378342 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
C9E45_RS22645 4378314..4380026 + 1713 Protein_4306 flagellar biosynthesis protein FlhA -
C9E45_RS22650 4380171..4380668 - 498 Protein_4307 REP-associated tyrosine transposase RayT -
C9E45_RS22655 4380844..4381617 - 774 WP_000543891.1 C40 family peptidase -
C9E45_RS22660 4381803..4382063 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
C9E45_RS22665 4382082..4382342 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
C9E45_RS22670 4382498..4383238 + 741 WP_001225679.1 murein L,D-transpeptidase -
C9E45_RS22675 4383209..4383976 - 768 WP_001301698.1 class II glutamine amidotransferase -
C9E45_RS22680 4384081..4384659 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T102560 WP_001303998.1 NZ_CP028671:4382082-4382342 [Escherichia coli]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T102560 NZ_CP028671:4382082-4382342 [Escherichia coli]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT102560 WP_000729705.1 NZ_CP028671:4381803-4382063 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT102560 NZ_CP028671:4381803-4382063 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References