102263

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2286468..2287263 Replicon chromosome
Accession NZ_CP028650
Organism Escherichia coli strain 124

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C9E53_RS11665 Protein ID WP_000854914.1
Coordinates 2286889..2287263 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag C9E53_RS11660 Protein ID WP_001280954.1
Coordinates 2286468..2286842 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E53_RS11625 2281823..2282728 + 906 WP_000203541.1 chemotaxis protein -
C9E53_RS11630 2282725..2283795 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
C9E53_RS11640 2284135..2284953 + 819 WP_001234682.1 DUF945 domain-containing protein -
C9E53_RS11645 2285044..2285529 + 486 WP_000214398.1 antirestriction protein -
C9E53_RS11650 2285545..2286021 + 477 WP_001186738.1 RadC family protein -
C9E53_RS11655 2286084..2286305 + 222 WP_001220314.1 DUF987 domain-containing protein -
C9E53_RS11660 2286468..2286842 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C9E53_RS11665 2286889..2287263 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C9E53_RS11670 2287260..2287751 + 492 WP_000976853.1 hypothetical protein -
C9E53_RS11675 2287763..2287960 + 198 WP_000839282.1 DUF957 domain-containing protein -
C9E53_RS11680 2288045..2288887 + 843 WP_001280481.1 DUF4942 domain-containing protein -
C9E53_RS11690 2289358..2290296 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
C9E53_RS11695 2290351..2291088 + 738 WP_000283664.1 zinc-binding phosphatase -
C9E53_RS11700 2291112..2291666 + 555 WP_001001917.1 molecular chaperone YcdY -
C9E53_RS11705 2291768..2292259 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 2285545..2297827 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T102263 WP_000854914.1 NZ_CP028650:2286889-2287263 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T102263 NZ_CP028650:2286889-2287263 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT102263 WP_001280954.1 NZ_CP028650:2286468-2286842 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT102263 NZ_CP028650:2286468-2286842 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References