10217

Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type I Classification (family/domain) AapB-IsoB/-
Location 865516..865671 Replicon chromosome
Accession NC_000915
Organism Helicobacter pylori 26695
T1TAdb ID TA03829

Toxin (Protein)


Gene name AapB Uniprot ID -
Locus tag - Protein ID -
Coordinates 865516..865644 (-) Length 43 a.a.

Antitoxin (RNA)


Gene name IsoB
Locus tag -
Coordinates 865570..865671 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP_RS03930 (HP0807) 860980..863357 - 2378 Protein_768 TonB-dependent receptor family protein -
HP_RS03935 (HP0808) 863551..863910 - 360 WP_000579175.1 holo-ACP synthase -
HP_RS03940 (HP0809) 863917..864468 - 552 WP_000797017.1 flagellar basal body-associated protein FliL -
HP_RS03945 (HP0810) 864477..865079 - 603 WP_001132760.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
HP_RS03950 (HP0811) 865058..865384 - 327 WP_000688953.1 hypothetical protein -
- 865516..865644 - 129 - - Toxin
- 865570..865671 + 102 - - Antitoxin
HP_RS03955 (HP0812) 865837..866847 - 1011 WP_001256047.1 class I SAM-dependent methyltransferase -
HP_RS03960 (HP0813) 866980..867597 + 618 WP_000404680.1 MBL fold metallo-hydrolase -
HP_RS03965 (HP0814) 867598..868365 + 768 WP_000952609.1 HesA/MoeB/ThiF family protein -
HP_RS03970 (HP0815) 868381..869154 + 774 WP_000366185.1 flagellar motor stator protein MotA -
HP_RS03975 (HP0816) 869157..869930 + 774 WP_001085308.1 flagellar motor protein MotB -
HP_RS03980 (HP0817) 869936..870373 + 438 WP_001875392.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 43 a.a.        Molecular weight: 5084.35 Da        Isoelectric Point: 11.2662

>T10217 - NC_000915:c865644-865516 [Helicobacter pylori 26695]
MKKLIKMLSYSKERRNIIRLSLLPSPSIIPKKKKTMLFELYF

Download         Length: 129 bp

>T10217 NC_000915:c865644-865516 [Helicobacter pylori 26695]
ATGAAAAAGTTGATTAAAATGCTAAGTTATAGTAAAGAAAGAAGGAATATAATACGCCTTTCGCTCTTACCTTCGCCGAG
CATTATACCAAAAAAAAAAAAAACGATGTTATTTGAACTTTATTTTTAA

Antitoxin


Download         Length: 102 bp

>AT10217 NC_000915:865570-865671 [Helicobacter pylori 26695]
CGAAGGTAAGAGCGAAAGGCGTATTATATTCCTTCTTTCTTTACTATAACTTAGCATTTTAATCAACTTTTTCATTAAAA
TGTCCTGACGCTCTTACCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References


(1) Cynthia M Sharma et al. (2010) The primary transcriptome of the major human pathogen Helicobacter pylori. Nature 464(7286):250-5. [PubMed:20164839] experimental


experimental experimental literature