Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 3462749..3462974 Replicon chromosome
Accession NZ_CP028641
Organism Escherichia coli strain 132

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag C9E56_RS18185 Protein ID WP_000813263.1
Coordinates 3462749..3462904 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 3462916..3462974 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E56_RS18150 3458203..3458916 - 714 WP_000261909.1 helix-turn-helix domain-containing protein -
C9E56_RS18155 3459054..3459250 - 197 Protein_3452 TrmB family transcriptional regulator -
C9E56_RS18160 3459537..3460355 - 819 WP_000265265.1 CPBP family intramembrane metalloprotease -
C9E56_RS18165 3460507..3460878 - 372 WP_000090264.1 antitermination protein -
C9E56_RS18170 3460868..3461239 - 372 WP_001217436.1 RusA family crossover junction endodeoxyribonuclease -
C9E56_RS18175 3461252..3462301 - 1050 WP_001265172.1 DUF968 domain-containing protein -
C9E56_RS18180 3462303..3462581 - 279 WP_001341388.1 hypothetical protein -
C9E56_RS18185 3462749..3462904 - 156 WP_000813263.1 type I toxin-antitoxin system toxin HokD Toxin
- 3462916..3462974 + 59 - - Antitoxin
C9E56_RS18205 3463509..3464282 + 774 WP_000160654.1 alpha/beta hydrolase -
C9E56_RS18210 3464634..3465047 - 414 WP_001151233.1 DUF977 family protein -
C9E56_RS18215 3465063..3465833 - 771 WP_000450992.1 DUF1627 domain-containing protein -
C9E56_RS18220 3465855..3466601 - 747 WP_000788751.1 ATP-binding protein -
C9E56_RS18225 3466608..3467699 - 1092 WP_001205823.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 52 a.a.        Molecular weight: 5722.86 Da        Isoelectric Point: 6.1531

>T102169 WP_000813263.1 NZ_CP028641:c3462904-3462749 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T102169 NZ_CP028641:c3462904-3462749 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT102169 NZ_CP028641:3462916-3462974 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References