Detailed information of TA system TA101918

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3462747..3462972
• Replicon: chromosome
• Accession: NZ_CP028620
• Organism: Escherichia coli strain 139

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: C9E63_RS18185
• Protein ID: WP_000813263.1
• Coordinates: 3462747..3462902 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3462914..3462972 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9E63_RS18150	3458201..3458914	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
C9E63_RS18155	3459052..3459248	-	197	Protein_3452	TrmB family transcriptional regulator	-
C9E63_RS18160	3459535..3460353	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
C9E63_RS18165	3460505..3460876	-	372	WP_000090264.1	antitermination protein	-
C9E63_RS18170	3460866..3461237	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
C9E63_RS18175	3461250..3462299	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
C9E63_RS18180	3462301..3462579	-	279	WP_001341388.1	hypothetical protein	-
C9E63_RS18185	3462747..3462902	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3462914..3462972	+	59	-	-	Antitoxin
C9E63_RS18205	3463507..3464280	+	774	WP_000160654.1	alpha/beta hydrolase	-
C9E63_RS18210	3464632..3465045	-	414	WP_001151233.1	DUF977 family protein	-
C9E63_RS18215	3465061..3465831	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
C9E63_RS18220	3465853..3466599	-	747	WP_000788751.1	ATP-binding protein	-
C9E63_RS18225	3466606..3467697	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T101918 WP_000813263.1 NZ_CP028620:c3462902-3462747 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T101918 NZ_CP028620:c3462902-3462747 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT101918 NZ_CP028620:3462914-3462972 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin