Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FicTA/- |
| Location | 50278..51889 | Replicon | plasmid pVbh_BscR1 |
| Accession | NZ_CP019790 | ||
| Organism | Bartonella schoenbuchensis R1 | ||
Toxin (Protein)
| Gene name | VbhT | Uniprot ID | - |
| Locus tag | BscR1v2_RS07925 | Protein ID | WP_153302026.1 |
| Coordinates | 50278..51714 (-) | Length | 479 a.a. |
Antitoxin (Protein)
| Gene name | VbhA | Uniprot ID | - |
| Locus tag | BscR1v2_RS07930 | Protein ID | WP_078690388.1 |
| Coordinates | 51701..51889 (-) | Length | 63 a.a. |
Genomic Context
Location: 45504..45791 (288 bp)
Type: Others
Protein ID: WP_078690383.1
Type: Others
Protein ID: WP_078690383.1
Location: 45797..46468 (672 bp)
Type: Others
Protein ID: WP_078690384.1
Type: Others
Protein ID: WP_078690384.1
Location: 46471..47325 (855 bp)
Type: Others
Protein ID: WP_078690385.1
Type: Others
Protein ID: WP_078690385.1
Location: 47240..48481 (1242 bp)
Type: Others
Protein ID: WP_078690386.1
Type: Others
Protein ID: WP_078690386.1
Location: 48494..49546 (1053 bp)
Type: Others
Protein ID: WP_010703103.1
Type: Others
Protein ID: WP_010703103.1
Location: 49569..49883 (315 bp)
Type: Others
Protein ID: WP_010703104.1
Type: Others
Protein ID: WP_010703104.1
Location: 49883..50224 (342 bp)
Type: Others
Protein ID: WP_078690387.1
Type: Others
Protein ID: WP_078690387.1
Location: 50278..51714 (1437 bp)
Type: Toxin
Protein ID: WP_153302026.1
Type: Toxin
Protein ID: WP_153302026.1
Location: 51701..51889 (189 bp)
Type: Antitoxin
Protein ID: WP_078690388.1
Type: Antitoxin
Protein ID: WP_078690388.1
Location: 51972..55691 (3720 bp)
Type: Others
Protein ID: WP_078690389.1
Type: Others
Protein ID: WP_078690389.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BscR1v2_RS07890 (BscR1v2_016850) | 45504..45791 | + | 288 | WP_078690383.1 | type IV secretion protein VblB7 | - |
| BscR1v2_RS07895 (BscR1v2_016860) | 45797..46468 | + | 672 | WP_078690384.1 | virB8 family protein | - |
| BscR1v2_RS07900 (BscR1v2_016870) | 46471..47325 | + | 855 | WP_078690385.1 | P-type conjugative transfer protein VirB9 | - |
| BscR1v2_RS07905 (BscR1v2_016880) | 47240..48481 | + | 1242 | WP_078690386.1 | type IV secretion system protein VirB10 | - |
| BscR1v2_RS07910 (BscR1v2_016890) | 48494..49546 | + | 1053 | WP_010703103.1 | P-type DNA transfer ATPase VirB11 | - |
| BscR1v2_RS07915 (BscR1v2_016900) | 49569..49883 | - | 315 | WP_010703104.1 | helix-turn-helix domain-containing protein | - |
| BscR1v2_RS07920 (BscR1v2_016910) | 49883..50224 | - | 342 | WP_078690387.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BscR1v2_RS07925 (BscR1v2_016920) | 50278..51714 | - | 1437 | WP_153302026.1 | Fic family protein | Toxin |
| BscR1v2_RS07930 (BscR1v2_016930) | 51701..51889 | - | 189 | WP_078690388.1 | antitoxin VbhA family protein | Antitoxin |
| BscR1v2_RS07935 (BscR1v2_016940) | 51972..55691 | - | 3720 | WP_078690389.1 | Ti-type conjugative transfer relaxase TraA | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | virB4 / virB11 | 1..55761 | 55761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 479 a.a. Molecular weight: 55346.66 Da Isoelectric Point: 9.8741
>T10186 WP_153302026.1 NZ_CP019790:c51714-50278 [Bartonella schoenbuchensis R1]
VRKYEGSNDPYTDPETGVMYNLLGIKDQARLERVESAFAYIRSFELGRTSISGKFDLDHMKKIHKKLFGDVYEWAGKTRL
VDIVKDNSKFAHYTQIESYAPQITQQLAREQHLRGLDANEFSQRAGYYMGELNALHPFREGNGRTLREFIWQLAREAGYH
IDWDRVERQEMTRASIESYYGNSDLMSALIRRNLTEFTVNRRVDVSQGINERVLSHIDIDKEWPQKGFNIAIQTTQQAPY
LSSYTDTSNLEEKAQNALRNEQSYVDTFKELNDHLKTIYKDPQAAALKIEQTILAGKGDKLPDILAKAPNKVGELRGSDR
LIDKLKSAGKERKAALYNVPLAISTIRRLQSFYKNSYEKHMDKLTREREQLKVEVPSLSQEAVAYMKNVEVGRNNYSKIP
ENINKEFVQLESALNRRFGKDVIYKRNFNLSKEIASKQTYDKKLVNELQTAIKFLQQRHIQKQNNLAITRTPSKGITR
VRKYEGSNDPYTDPETGVMYNLLGIKDQARLERVESAFAYIRSFELGRTSISGKFDLDHMKKIHKKLFGDVYEWAGKTRL
VDIVKDNSKFAHYTQIESYAPQITQQLAREQHLRGLDANEFSQRAGYYMGELNALHPFREGNGRTLREFIWQLAREAGYH
IDWDRVERQEMTRASIESYYGNSDLMSALIRRNLTEFTVNRRVDVSQGINERVLSHIDIDKEWPQKGFNIAIQTTQQAPY
LSSYTDTSNLEEKAQNALRNEQSYVDTFKELNDHLKTIYKDPQAAALKIEQTILAGKGDKLPDILAKAPNKVGELRGSDR
LIDKLKSAGKERKAALYNVPLAISTIRRLQSFYKNSYEKHMDKLTREREQLKVEVPSLSQEAVAYMKNVEVGRNNYSKIP
ENINKEFVQLESALNRRFGKDVIYKRNFNLSKEIASKQTYDKKLVNELQTAIKFLQQRHIQKQNNLAITRTPSKGITR
Download Length: 1437 bp
>T10186 NZ_CP019790:c51714-50278 [Bartonella schoenbuchensis R1]
GTGAGGAAATATGAGGGTAGCAACGATCCTTATACTGATCCAGAAACTGGTGTTATGTATAATCTGCTTGGAATTAAAGA
CCAAGCCAGATTGGAGCGTGTAGAATCTGCTTTCGCTTATATAAGGTCTTTTGAGCTTGGGCGTACTTCTATTAGCGGTA
AGTTCGATCTAGATCACATGAAAAAAATCCACAAAAAGCTGTTTGGTGACGTCTATGAATGGGCAGGAAAGACTCGTTTA
GTGGATATTGTCAAAGATAATAGTAAATTTGCTCATTATACTCAAATTGAAAGTTACGCACCGCAGATTACACAACAGCT
TGCAAGAGAACAACATTTACGTGGTCTTGACGCTAATGAATTTAGCCAGAGGGCTGGATATTACATGGGCGAATTGAATG
CGTTGCACCCGTTTCGAGAAGGTAATGGACGTACTTTACGTGAATTTATCTGGCAACTTGCTCGTGAAGCTGGTTATCAT
ATCGACTGGGATCGTGTAGAGCGACAAGAAATGACGCGTGCGTCAATTGAATCATATTATGGCAACTCTGATTTAATGTC
TGCGCTAATCCGTAGAAACCTCACTGAATTTACAGTAAATAGAAGAGTTGATGTTTCTCAAGGTATTAATGAACGAGTTC
TTTCTCACATTGATATAGATAAAGAATGGCCACAAAAAGGTTTTAATATAGCAATACAAACAACACAACAGGCACCATAT
CTTTCTTCTTATACAGACACTTCTAATCTAGAAGAGAAAGCGCAAAACGCTCTTAGAAATGAACAATCTTATGTTGATAC
TTTTAAAGAATTAAACGATCATTTGAAGACTATCTATAAGGATCCCCAAGCAGCTGCACTTAAGATTGAACAAACAATTT
TAGCAGGCAAGGGGGATAAATTACCTGATATTTTAGCTAAAGCACCTAATAAAGTTGGTGAACTGCGCGGATCAGACCGT
TTAATAGACAAACTAAAATCAGCAGGAAAAGAACGAAAAGCTGCACTTTATAATGTTCCTCTTGCAATTTCTACGATTAG
AAGACTTCAATCATTTTATAAAAATTCCTATGAGAAGCATATGGACAAACTTACACGTGAACGTGAACAATTAAAGGTTG
AAGTGCCTTCTCTCTCTCAAGAAGCTGTCGCTTATATGAAAAATGTTGAAGTTGGCCGTAATAATTATTCCAAGATACCA
GAGAACATTAATAAAGAATTTGTGCAGCTTGAAAGTGCTTTAAATAGGCGTTTTGGAAAGGATGTAATCTATAAGCGAAA
TTTTAACTTATCAAAAGAAATAGCCTCAAAACAGACTTATGATAAAAAGCTTGTCAATGAACTTCAAACGGCAATAAAAT
TTCTACAACAAAGACATATACAAAAACAAAACAATCTTGCGATAACACGCACGCCTTCAAAGGGAATTACAAGGTAA
GTGAGGAAATATGAGGGTAGCAACGATCCTTATACTGATCCAGAAACTGGTGTTATGTATAATCTGCTTGGAATTAAAGA
CCAAGCCAGATTGGAGCGTGTAGAATCTGCTTTCGCTTATATAAGGTCTTTTGAGCTTGGGCGTACTTCTATTAGCGGTA
AGTTCGATCTAGATCACATGAAAAAAATCCACAAAAAGCTGTTTGGTGACGTCTATGAATGGGCAGGAAAGACTCGTTTA
GTGGATATTGTCAAAGATAATAGTAAATTTGCTCATTATACTCAAATTGAAAGTTACGCACCGCAGATTACACAACAGCT
TGCAAGAGAACAACATTTACGTGGTCTTGACGCTAATGAATTTAGCCAGAGGGCTGGATATTACATGGGCGAATTGAATG
CGTTGCACCCGTTTCGAGAAGGTAATGGACGTACTTTACGTGAATTTATCTGGCAACTTGCTCGTGAAGCTGGTTATCAT
ATCGACTGGGATCGTGTAGAGCGACAAGAAATGACGCGTGCGTCAATTGAATCATATTATGGCAACTCTGATTTAATGTC
TGCGCTAATCCGTAGAAACCTCACTGAATTTACAGTAAATAGAAGAGTTGATGTTTCTCAAGGTATTAATGAACGAGTTC
TTTCTCACATTGATATAGATAAAGAATGGCCACAAAAAGGTTTTAATATAGCAATACAAACAACACAACAGGCACCATAT
CTTTCTTCTTATACAGACACTTCTAATCTAGAAGAGAAAGCGCAAAACGCTCTTAGAAATGAACAATCTTATGTTGATAC
TTTTAAAGAATTAAACGATCATTTGAAGACTATCTATAAGGATCCCCAAGCAGCTGCACTTAAGATTGAACAAACAATTT
TAGCAGGCAAGGGGGATAAATTACCTGATATTTTAGCTAAAGCACCTAATAAAGTTGGTGAACTGCGCGGATCAGACCGT
TTAATAGACAAACTAAAATCAGCAGGAAAAGAACGAAAAGCTGCACTTTATAATGTTCCTCTTGCAATTTCTACGATTAG
AAGACTTCAATCATTTTATAAAAATTCCTATGAGAAGCATATGGACAAACTTACACGTGAACGTGAACAATTAAAGGTTG
AAGTGCCTTCTCTCTCTCAAGAAGCTGTCGCTTATATGAAAAATGTTGAAGTTGGCCGTAATAATTATTCCAAGATACCA
GAGAACATTAATAAAGAATTTGTGCAGCTTGAAAGTGCTTTAAATAGGCGTTTTGGAAAGGATGTAATCTATAAGCGAAA
TTTTAACTTATCAAAAGAAATAGCCTCAAAACAGACTTATGATAAAAAGCTTGTCAATGAACTTCAAACGGCAATAAAAT
TTCTACAACAAAGACATATACAAAAACAAAACAATCTTGCGATAACACGCACGCCTTCAAAGGGAATTACAAGGTAA
Antitoxin
Download Length: 63 a.a. Molecular weight: 7270.24 Da Isoelectric Point: 4.2939
>AT10186 WP_078690388.1 NZ_CP019790:c51889-51701 [Bartonella schoenbuchensis R1]
MLSEEEIEYRRRDARNALASQRLEGLEPDPQVVAQMERVVVGELETSDVIKDLMERIKREEI
MLSEEEIEYRRRDARNALASQRLEGLEPDPQVVAQMERVVVGELETSDVIKDLMERIKREEI
Download Length: 189 bp
>AT10186 NZ_CP019790:c51889-51701 [Bartonella schoenbuchensis R1]
ATGTTGAGCGAGGAAGAAATCGAATACCGTCGCCGTGATGCTAGAAATGCGTTGGCTAGTCAACGTTTAGAGGGTTTGGA
ACCAGATCCACAAGTCGTTGCACAAATGGAGCGTGTTGTTGTTGGAGAGCTTGAAACAAGTGATGTAATCAAGGATTTGA
TGGAACGGATAAAACGTGAGGAAATATGA
ATGTTGAGCGAGGAAGAAATCGAATACCGTCGCCGTGATGCTAGAAATGCGTTGGCTAGTCAACGTTTAGAGGGTTTGGA
ACCAGATCCACAAGTCGTTGCACAAATGGAGCGTGTTGTTGTTGGAGAGCTTGAAACAAGTGATGTAATCAAGGATTTGA
TGGAACGGATAAAACGTGAGGAAATATGA
Similar Proteins
Only experimentally validated proteins are listed.
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10184 | Campylobacter fetus subsp. venerealis str. 84-112 | 35.185 | 96.861 | 0.341 |
Showing 1 to 1 of 1 rows
Multiple sequence alignment
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| No matching records found | ||||
References
(1) Alexander Harms et al. (2017) A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella. PLoS Genetics 13(10):e1007077. [PubMed:29073136]