Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FicTA/- |
| Location | 14087..14987 | Replicon | plasmid II |
| Accession | NZ_HG004427 | ||
| Organism | Campylobacter fetus subsp. venerealis str. 84-112 | ||
Toxin (Protein)
| Gene name | Fic | Uniprot ID | - |
| Locus tag | CSG_RS09935 | Protein ID | WP_046037525.1 |
| Coordinates | 14316..14987 (+) | Length | 224 a.a. |
Antitoxin (Protein)
| Gene name | Fti | Uniprot ID | A0A7D7Q4X0 |
| Locus tag | CSG_RS09930 | Protein ID | WP_046037523.1 |
| Coordinates | 14087..14323 (+) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CSG_RS10325 (CSG_c130) | 10084..10839 | + | 756 | WP_052690294.1 | hypothetical protein | - |
| CSG_RS09910 (CSG_c140) | 10823..11923 | - | 1101 | WP_035171451.1 | transposase | - |
| CSG_RS09915 (CSG_c150) | 11901..12356 | - | 456 | WP_035171449.1 | IS200/IS605 family transposase | - |
| CSG_RS09920 (CSG_c160) | 12460..13251 | + | 792 | Protein_15 | type IV secretory system conjugative DNA transfer family protein | - |
| CSG_RS09925 (CSG_c170) | 13263..13970 | + | 708 | WP_002850984.1 | conjugal transfer protein TraL | - |
| CSG_RS09930 (CSG_c180) | 14087..14323 | + | 237 | WP_046037523.1 | hypothetical protein | Antitoxin |
| CSG_RS09935 (CSG_c190) | 14316..14987 | + | 672 | WP_046037525.1 | Fic family protein | Toxin |
| CSG_RS09940 (CSG_c200) | 15048..15506 | + | 459 | WP_046037527.1 | S26 family signal peptidase | - |
| CSG_RS09945 (CSG_c210) | 15503..15874 | + | 372 | WP_002850989.1 | hypothetical protein | - |
| CSG_RS09950 (CSG_c220) | 15985..16671 | + | 687 | WP_002850991.1 | AAA family ATPase | - |
| CSG_RS09955 (CSG_c230) | 16675..16884 | + | 210 | WP_046037529.1 | hypothetical protein | - |
| CSG_RS09960 (CSG_c240) | 16964..18526 | - | 1563 | WP_052690295.1 | relaxase/mobilization nuclease domain-containing protein | - |
| CSG_RS09965 (CSG_c250) | 18501..18869 | - | 369 | WP_046037531.1 | DNA transfer protein | - |
| CSG_RS09970 (CSG_c260) | 19094..19309 | + | 216 | WP_046037533.1 | hypothetical protein | - |
| CSG_RS09975 (CSG_c270) | 19302..19577 | + | 276 | WP_046037534.1 | type II toxin-antitoxin system YafQ family toxin | - |
| CSG_RS09980 (CSG_c280) | 19574..19903 | + | 330 | WP_046037535.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..61142 | 61142 | |
| - | flank | IS/Tn | - | - | 11901..12356 | 455 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 224 a.a. Molecular weight: 25677.75 Da Isoelectric Point: 9.2692
>T10184 WP_046037525.1 NZ_HG004427:14316-14987 [Campylobacter fetus subsp. venerealis str. 84-112]
MIDKVLKFLDDGIPKNDFDKQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFEDVYTWA
GKDRNDMKIYGFMSKGNSVFCAGEYIPKEAEKIFTNLQNQNYFKECKDLNHFAKDIANFMSDLNALHPFREGNGRIQRIF
INQLAKNAGYKLDLNLIPKEKIITASIEAMECKNTKLEALIKTNLKSFKQNLEKENALGLSLC
MIDKVLKFLDDGIPKNDFDKQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFEDVYTWA
GKDRNDMKIYGFMSKGNSVFCAGEYIPKEAEKIFTNLQNQNYFKECKDLNHFAKDIANFMSDLNALHPFREGNGRIQRIF
INQLAKNAGYKLDLNLIPKEKIITASIEAMECKNTKLEALIKTNLKSFKQNLEKENALGLSLC
Download Length: 672 bp
>T10184 NZ_HG004427:14316-14987 [Campylobacter fetus subsp. venerealis str. 84-112]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGACAAACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAACGAGAAAGAGAAATTACATTAAAAAAACAATTAAAACTACAACTTA
ATCCTATTAAAGGCAATTTTGATTATCAACACTTAAAAGATATACATAAAGCACTTTTTGAAGATGTTTATACTTGGGCC
GGAAAAGACAGAAATGATATGAAAATTTACGGCTTTATGTCAAAAGGGAATTCAGTATTTTGTGCAGGAGAATATATACC
AAAAGAAGCAGAAAAAATTTTTACTAATTTGCAAAATCAGAACTATTTTAAAGAATGCAAAGATTTAAATCATTTTGCAA
AAGATATAGCTAATTTTATGTCTGATTTGAATGCTCTTCATCCTTTTCGTGAAGGTAACGGCAGAATTCAAAGAATATTT
ATAAATCAACTTGCAAAAAATGCTGGATACAAACTAGATTTAAATTTAATTCCTAAAGAAAAAATTATAACTGCTTCCAT
AGAAGCTATGGAGTGTAAAAATACAAAACTAGAAGCCTTAATAAAAACAAATCTAAAAAGTTTCAAGCAAAATTTAGAAA
AAGAAAATGCATTAGGATTATCCTTATGTTAA
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGACAAACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAACGAGAAAGAGAAATTACATTAAAAAAACAATTAAAACTACAACTTA
ATCCTATTAAAGGCAATTTTGATTATCAACACTTAAAAGATATACATAAAGCACTTTTTGAAGATGTTTATACTTGGGCC
GGAAAAGACAGAAATGATATGAAAATTTACGGCTTTATGTCAAAAGGGAATTCAGTATTTTGTGCAGGAGAATATATACC
AAAAGAAGCAGAAAAAATTTTTACTAATTTGCAAAATCAGAACTATTTTAAAGAATGCAAAGATTTAAATCATTTTGCAA
AAGATATAGCTAATTTTATGTCTGATTTGAATGCTCTTCATCCTTTTCGTGAAGGTAACGGCAGAATTCAAAGAATATTT
ATAAATCAACTTGCAAAAAATGCTGGATACAAACTAGATTTAAATTTAATTCCTAAAGAAAAAATTATAACTGCTTCCAT
AGAAGCTATGGAGTGTAAAAATACAAAACTAGAAGCCTTAATAAAAACAAATCTAAAAAGTTTCAAGCAAAATTTAGAAA
AAGAAAATGCATTAGGATTATCCTTATGTTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 9009.20 Da Isoelectric Point: 4.4547
>AT10184 WP_046037523.1 NZ_HG004427:14087-14323 [Campylobacter fetus subsp. venerealis str. 84-112]
MTYPEVHSLEESLAILKKYKDDVSKKDYEEIKSTICGHAIENMFANEKDVIDMIKIAKNEANADEIIAEYKKEWGIND
MTYPEVHSLEESLAILKKYKDDVSKKDYEEIKSTICGHAIENMFANEKDVIDMIKIAKNEANADEIIAEYKKEWGIND
Download Length: 237 bp
>AT10184 NZ_HG004427:14087-14323 [Campylobacter fetus subsp. venerealis str. 84-112]
ATGACATATCCAGAAGTACATAGTTTAGAAGAAAGTTTAGCAATACTTAAAAAATATAAAGATGATGTAAGCAAAAAAGA
CTATGAAGAAATTAAATCTACCATTTGCGGACATGCTATTGAAAATATGTTTGCAAATGAAAAAGATGTTATCGATATGA
TAAAAATTGCAAAAAATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAAAGAATGGGGAATAAATGATTGA
ATGACATATCCAGAAGTACATAGTTTAGAAGAAAGTTTAGCAATACTTAAAAAATATAAAGATGATGTAAGCAAAAAAGA
CTATGAAGAAATTAAATCTACCATTTGCGGACATGCTATTGAAAATATGTTTGCAAATGAAAAAGATGTTATCGATATGA
TAAAAATTGCAAAAAATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAAAGAATGGGGAATAAATGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10186 | Bartonella schoenbuchensis R1 |
35.185 |
96.861 |
0.341 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Hanna Sprenger et al. (2017) Fic Proteins of Campylobacter fetus subsp. venerealis Form a Network of Functional Toxin-Antitoxin Systems. Frontiers in Microbiology 8:1965. [PubMed:29089929]