Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3254527..3255322 Replicon chromosome
Accession NZ_CP028614
Organism Escherichia coli strain 141

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C9E65_RS17015 Protein ID WP_000854914.1
Coordinates 3254527..3254901 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag C9E65_RS17020 Protein ID WP_001416641.1
Coordinates 3254948..3255322 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E65_RS16975 3249531..3250022 - 492 WP_001301587.1 DUF1097 domain-containing protein -
C9E65_RS16980 3250124..3250678 - 555 WP_001001917.1 molecular chaperone YcdY -
C9E65_RS16985 3250702..3251439 - 738 WP_000283664.1 zinc-binding phosphatase -
C9E65_RS16990 3251494..3252432 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
C9E65_RS17000 3252903..3253745 - 843 WP_001280481.1 DUF4942 domain-containing protein -
C9E65_RS17005 3253830..3254027 - 198 WP_000839282.1 DUF957 domain-containing protein -
C9E65_RS17010 3254039..3254530 - 492 WP_000976853.1 hypothetical protein -
C9E65_RS17015 3254527..3254901 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C9E65_RS17020 3254948..3255322 - 375 WP_001416641.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C9E65_RS17025 3255485..3255706 - 222 WP_001220314.1 DUF987 domain-containing protein -
C9E65_RS17030 3255769..3256245 - 477 WP_001186738.1 RadC family protein -
C9E65_RS17035 3256261..3256746 - 486 WP_000214398.1 antirestriction protein -
C9E65_RS17040 3256837..3257655 - 819 WP_001234682.1 DUF945 domain-containing protein -
C9E65_RS17050 3257995..3259065 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
C9E65_RS17055 3259062..3259967 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3245913..3256746 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T101845 WP_000854914.1 NZ_CP028614:c3254901-3254527 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T101845 NZ_CP028614:c3254901-3254527 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13778.61 Da        Isoelectric Point: 6.6249

>AT101845 WP_001416641.1 NZ_CP028614:c3255322-3254948 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGFCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT101845 NZ_CP028614:c3255322-3254948 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTTCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5


Antitoxin

Source ID Structure

References