Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/- |
| Location | 69672..70615 | Replicon | chromosome |
| Accession | NADK01000036 | ||
| Organism | Mycobacterium sp. MHSD3 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | B5566_13860 | Protein ID | PKQ57431.1 |
| Coordinates | 70028..70615 (+) | Length | 196 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | - |
| Locus tag | B5566_13855 | Protein ID | PKQ57430.1 |
| Coordinates | 69672..70031 (+) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B5566_13840 | 64870..65832 | - | 963 | PKQ57483.1 | ATP-binding protein | - |
| B5566_13845 | 65888..67903 | - | 2016 | PKQ57429.1 | transposase | - |
| B5566_13850 | 67885..68667 | - | 783 | PKQ57484.1 | hypothetical protein | - |
| B5566_13855 | 69672..70031 | + | 360 | PKQ57430.1 | hypothetical protein | Antitoxin |
| B5566_13860 | 70028..70615 | + | 588 | PKQ57431.1 | ATPase | Toxin |
| B5566_13865 | 70754..71122 | + | 369 | PKQ57432.1 | hypothetical protein | - |
| B5566_13870 | 71119..71331 | + | 213 | PKQ57433.1 | hypothetical protein | - |
| B5566_13875 | 71532..71765 | + | 234 | PKQ57434.1 | hypothetical protein | - |
| B5566_13880 | 72464..74690 | + | 2227 | Protein_74 | peptidase S9 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 196 a.a. Molecular weight: 21640.78 Da Isoelectric Point: 8.5326
>T10183 PKQ57431.1 NADK01000036:70028-70615 [Mycobacterium sp. MHSD3]
VKRLDLIVGPNGSGKTTFVAKFLAPLLHESVFVNADEIAKQRWPDEDPAPRAYEAARIAEQTRQALISQGRPFIAETVFS
HPSKLDLIRSAQAADYTVRLLVLLVPEELTVQRVAARVEAGGHSVPIEKIRARYERLWPLVVDAIALADSSVVFDNSSEP
GPRVVARMTRGQVVGTLTWPQWTPAPLWQRWTDSA
VKRLDLIVGPNGSGKTTFVAKFLAPLLHESVFVNADEIAKQRWPDEDPAPRAYEAARIAEQTRQALISQGRPFIAETVFS
HPSKLDLIRSAQAADYTVRLLVLLVPEELTVQRVAARVEAGGHSVPIEKIRARYERLWPLVVDAIALADSSVVFDNSSEP
GPRVVARMTRGQVVGTLTWPQWTPAPLWQRWTDSA
Download Length: 588 bp
>T10183 NADK01000036:70028-70615 [Mycobacterium sp. MHSD3]
GTGAAACGGCTCGATCTGATCGTCGGTCCCAATGGCTCAGGCAAGACAACCTTTGTCGCCAAGTTTCTCGCACCGCTGCT
GCATGAATCGGTGTTCGTCAACGCCGACGAGATCGCCAAGCAGCGCTGGCCCGACGAGGACCCTGCCCCGCGGGCATACG
AGGCTGCGCGCATCGCCGAGCAGACACGGCAAGCGTTGATCAGCCAGGGGCGCCCGTTCATCGCCGAGACAGTGTTCTCA
CATCCCTCAAAGCTGGACCTGATTCGATCAGCACAGGCCGCGGACTACACCGTCCGCCTACTGGTGCTTCTGGTGCCTGA
GGAGCTGACAGTGCAGCGTGTAGCGGCCCGGGTAGAAGCCGGCGGTCACAGTGTTCCGATCGAGAAGATCCGTGCGCGCT
ATGAGCGCTTATGGCCACTTGTTGTGGATGCGATCGCCCTGGCCGATTCGAGCGTTGTCTTCGACAACAGCTCTGAGCCA
GGGCCGCGTGTTGTGGCCCGGATGACGCGTGGCCAGGTCGTAGGAACGCTGACCTGGCCACAGTGGACACCCGCTCCTTT
GTGGCAGCGGTGGACAGACAGCGCGTAG
GTGAAACGGCTCGATCTGATCGTCGGTCCCAATGGCTCAGGCAAGACAACCTTTGTCGCCAAGTTTCTCGCACCGCTGCT
GCATGAATCGGTGTTCGTCAACGCCGACGAGATCGCCAAGCAGCGCTGGCCCGACGAGGACCCTGCCCCGCGGGCATACG
AGGCTGCGCGCATCGCCGAGCAGACACGGCAAGCGTTGATCAGCCAGGGGCGCCCGTTCATCGCCGAGACAGTGTTCTCA
CATCCCTCAAAGCTGGACCTGATTCGATCAGCACAGGCCGCGGACTACACCGTCCGCCTACTGGTGCTTCTGGTGCCTGA
GGAGCTGACAGTGCAGCGTGTAGCGGCCCGGGTAGAAGCCGGCGGTCACAGTGTTCCGATCGAGAAGATCCGTGCGCGCT
ATGAGCGCTTATGGCCACTTGTTGTGGATGCGATCGCCCTGGCCGATTCGAGCGTTGTCTTCGACAACAGCTCTGAGCCA
GGGCCGCGTGTTGTGGCCCGGATGACGCGTGGCCAGGTCGTAGGAACGCTGACCTGGCCACAGTGGACACCCGCTCCTTT
GTGGCAGCGGTGGACAGACAGCGCGTAG
Antitoxin
Download Length: 120 a.a. Molecular weight: 13117.66 Da Isoelectric Point: 4.7938
>AT10183 PKQ57430.1 NADK01000036:69672-70031 [Mycobacterium sp. MHSD3]
MAAPVDRPTRVASDLLDSAAAEGARQSRSAKQQLDHWARLGREVSSQDNVSRRRVEAALSGQLSMRELTPEEGVVFNAEI
EVELERRIAATHLQDELRAEGMRVVVLNDAGEIVQYPPA
MAAPVDRPTRVASDLLDSAAAEGARQSRSAKQQLDHWARLGREVSSQDNVSRRRVEAALSGQLSMRELTPEEGVVFNAEI
EVELERRIAATHLQDELRAEGMRVVVLNDAGEIVQYPPA
Download Length: 360 bp
>AT10183 NADK01000036:69672-70031 [Mycobacterium sp. MHSD3]
ATGGCGGCTCCGGTAGATCGCCCGACGCGCGTGGCGTCGGATCTTTTGGACAGCGCTGCGGCAGAAGGTGCGCGGCAGAG
TCGCTCGGCTAAGCAGCAGCTCGACCACTGGGCGCGGCTGGGTCGCGAAGTGAGTAGCCAGGACAACGTCTCGCGGCGGC
GGGTAGAGGCCGCGCTGTCCGGCCAGCTGAGCATGCGTGAGCTCACCCCGGAAGAGGGCGTGGTTTTCAACGCCGAAATC
GAGGTCGAGCTGGAGCGGCGGATCGCCGCAACGCACCTGCAAGATGAGCTGAGGGCCGAGGGTATGCGAGTCGTGGTTCT
CAATGACGCCGGCGAGATTGTGCAGTACCCACCGGCGTGA
ATGGCGGCTCCGGTAGATCGCCCGACGCGCGTGGCGTCGGATCTTTTGGACAGCGCTGCGGCAGAAGGTGCGCGGCAGAG
TCGCTCGGCTAAGCAGCAGCTCGACCACTGGGCGCGGCTGGGTCGCGAAGTGAGTAGCCAGGACAACGTCTCGCGGCGGC
GGGTAGAGGCCGCGCTGTCCGGCCAGCTGAGCATGCGTGAGCTCACCCCGGAAGAGGGCGTGGTTTTCAACGCCGAAATC
GAGGTCGAGCTGGAGCGGCGGATCGCCGCAACGCACCTGCAAGATGAGCTGAGGGCCGAGGGTATGCGAGTCGTGGTTCT
CAATGACGCCGGCGAGATTGTGCAGTACCCACCGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10144 | Mycobacterium tuberculosis H37Rv |
62.694 |
98.974 |
0.621 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10144 | Mycobacterium tuberculosis H37Rv |
67.544 |
95.798 |
0.647 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Daniel Jaén-Luchoro et al. (2017) First insights into a type II toxin-antitoxin system from the clinical isolate Mycobacterium sp. MHSD3, similar to epsilon/zeta systems. PloS One 12(12):e0189459. [PubMed:29236773]