Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3273123..3273918 Replicon chromosome
Accession NZ_CP028596
Organism Escherichia coli strain 149

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C9E71_RS17185 Protein ID WP_000854914.1
Coordinates 3273123..3273497 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag C9E71_RS17190 Protein ID WP_001280954.1
Coordinates 3273544..3273918 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E71_RS17145 3268127..3268618 - 492 WP_001301587.1 DUF1097 domain-containing protein -
C9E71_RS17150 3268720..3269274 - 555 WP_001001917.1 molecular chaperone YcdY -
C9E71_RS17155 3269298..3270035 - 738 WP_000283664.1 zinc-binding phosphatase -
C9E71_RS17160 3270090..3271028 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
C9E71_RS17170 3271499..3272341 - 843 WP_001280481.1 DUF4942 domain-containing protein -
C9E71_RS17175 3272426..3272623 - 198 WP_000839282.1 DUF957 domain-containing protein -
C9E71_RS17180 3272635..3273126 - 492 WP_000976853.1 hypothetical protein -
C9E71_RS17185 3273123..3273497 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C9E71_RS17190 3273544..3273918 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C9E71_RS17195 3274081..3274302 - 222 WP_001220314.1 DUF987 domain-containing protein -
C9E71_RS17200 3274365..3274841 - 477 WP_001186738.1 RadC family protein -
C9E71_RS17205 3274857..3275342 - 486 WP_000214398.1 antirestriction protein -
C9E71_RS17210 3275433..3276251 - 819 WP_001234682.1 DUF945 domain-containing protein -
C9E71_RS17220 3276591..3277661 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
C9E71_RS17225 3277658..3278563 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3264509..3275342 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T101633 WP_000854914.1 NZ_CP028596:c3273497-3273123 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T101633 NZ_CP028596:c3273497-3273123 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT101633 WP_001280954.1 NZ_CP028596:c3273918-3273544 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT101633 NZ_CP028596:c3273918-3273544 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References