Detailed information of TA system TA101596

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3608396..3608621
• Replicon: chromosome
• Accession: NZ_CP028592
• Organism: Escherichia coli strain 150

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: C9E72_RS19200
• Protein ID: WP_000813263.1
• Coordinates: 3608396..3608551 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3608563..3608621 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9E72_RS19165	3603850..3604563	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
C9E72_RS19170	3604701..3604897	-	197	Protein_3645	TrmB family transcriptional regulator	-
C9E72_RS19175	3605184..3606002	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
C9E72_RS19180	3606154..3606525	-	372	WP_000090264.1	antitermination protein	-
C9E72_RS19185	3606515..3606886	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
C9E72_RS19190	3606899..3607948	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
C9E72_RS19195	3607950..3608228	-	279	WP_001341388.1	hypothetical protein	-
C9E72_RS19200	3608396..3608551	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3608563..3608621	+	59	-	-	Antitoxin
C9E72_RS19220	3609156..3609929	+	774	WP_000160654.1	alpha/beta hydrolase	-
C9E72_RS19225	3610281..3610694	-	414	WP_001151233.1	DUF977 family protein	-
C9E72_RS19230	3610710..3611480	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
C9E72_RS19235	3611502..3612248	-	747	WP_000788751.1	ATP-binding protein	-
C9E72_RS19240	3612255..3613346	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T101596 WP_000813263.1 NZ_CP028592:c3608551-3608396 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T101596 NZ_CP028592:c3608551-3608396 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT101596 NZ_CP028592:3608563-3608621 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin