Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type I Classification (family/domain) /-
Location 2504847..2505101 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name fst Uniprot ID -
Locus tag - Protein ID -
Coordinates 2504847..2505101 (+) Length 85 a.a.

Antitoxin (RNA)


Gene name -
Locus tag -
Coordinates - ()

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS12735 2500240..2500407 - 168 WP_001793334.1 hypothetical protein -
MW_RS12745 (MW2351) 2500638..2502371 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
MW_RS12750 (MW2352) 2502396..2504159 - 1764 WP_001064815.1 ABC transporter ATP-binding protein/permease -
MW_RS12760 2504843..2504950 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin -
MW_RS12765 (MW2355) 2505084..2505470 - 387 WP_000779360.1 flippase GtxA -
MW_RS12770 (MW2356) 2505728..2506870 + 1143 WP_001176871.1 glycerate kinase -
MW_RS12775 (MW2357) 2506930..2507589 + 660 WP_000831301.1 membrane protein -
MW_RS12780 (MW2358) 2507771..2508982 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MW_RS12785 (MW2359) 2509105..2509578 - 474 WP_000456497.1 GyrI-like domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 9837.93 Da        Isoelectric Point: 10.9082

>T10155 - NC_003923:2504847-2505101 [Staphylococcus aureus subsp. aureus MW2]
MSPFLLLRVRNQCAKNATRQPLKAEVMMSINKLNIRHTPPLCVKVTPEMLGDHYIISFIYYISRNIKVRVKRFLVVYATL
ITIF

Download         Length: 255 bp

>T10155 NC_003923:2504847-2505101 [Staphylococcus aureus subsp. aureus MW2]
TTGTCACCTTTTTTATTGTTGCGCGTTCGTAACCAATGTGCAAAAAACGCAACAAGACAGCCGCTTAAAGCTGAAGTCAT
GATGTCAATTAATAAATTGAACATCCGTCATACACCTCCTCTCTGCGTTAAAGTAACGCCCGAGATGTTAGGCGACCATT
ATATTATATCATTTATTTATTATATTTCACGCAATATTAAAGTTCGAGTAAAGCGTTTTTTAGTGGTTTACGCTACTTTA
ATTACTATCTTTTAA

Antitoxin


Download         Length: 1 bp

>AT10155 UFRD01000002:c4600708-4600427 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGATAGTCCGCGC
TGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTGTTGATGCCG
CCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCGAATGAAAAG
CTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References


(1) Gul Habib et al. (2018) Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus. Toxins 10(11):473. [PubMed:30441856] experimental


experimental experimental literature